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Suppression of radiation-induced large deletions by combined treatments with a tobacco-specific nitrosamine in the lung of gpt delta transgenic mice
https://repo.qst.go.jp/records/62520
https://repo.qst.go.jp/records/62520e9c98ccf-10ef-4011-94e1-139cfe078730
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2008-04-16 | |||||
| タイトル | ||||||
| タイトル | Suppression of radiation-induced large deletions by combined treatments with a tobacco-specific nitrosamine in the lung of gpt delta transgenic mice | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Ikeda, Megumi
× Ikeda, Megumi× Masumura, Kenichi× Sakamoto, Yasuteru× Bing, Wang× Nenoi, Mitsuru× Sakuma, Keiko× Hayata, Isamu× Nohmi, Takehiko× 池田 恵× 増村 健一× 坂元 康晃× 王 冰× 根井 充× 早田 勇× 能美 健彦 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | It is important to evaluate the health effects of low-dose-rate or low-dose radiation in combination with chemicals as humans are exposed to a variety of chemical agents. Here, we examined combined genotoxic effects of low-dose-rate radiation and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), the most carcinogenic tobacco-specific nitrosamine, in the lung of gpt delta transgenic mice. In this mouse model, base substitutions and deletions can be separately analyzed by gpt and Spi- selections, respectively. Female gpt delta mice were treated either with gamma-irradiation alone at a dose rate of 0.5, 1.0 or 1.5 mGy/h for 22 h/day for 31 days or its combination with NNK at a dose of 2 mg/mouse/day, i.p. for four consecutive days in the middle course of irradiation. In the gpt selection, the NNK treatments enhanced the mutation frequencies (MFs) significantly, but no obvious combined effects of gamma-irradiation were observable at any given radiation dose. In contrast, NNK treatments appeared to suppress the Spi- large deletions. In the Spi- selection, the MFs of deletions more than 1 kb in size increased in a dose-dependent manner. When NNK treatments were combined, the dose-response curve became bell-shaped where the MF at the highest radiation dose decreased substantially. These results suggest that NNK treatments may elicit an adaptive response that eliminates cells bearing radiation-induced double-strand breaks (DSBs) in DNA. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | New Nuclear Research Symposium "Biological Responses to Low Dose Radiation" | |||||
| 発表年月日 | ||||||
| 日付 | 2007-11-13 | |||||
| 日付タイプ | Issued | |||||
