{"created":"2023-05-15T14:45:45.716348+00:00","id":62520,"links":{},"metadata":{"_buckets":{"deposit":"ad1f6f7d-4f98-4f23-8296-64cacbd99d2c"},"_deposit":{"created_by":1,"id":"62520","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"62520"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00062520","sets":["10:29"]},"author_link":["617661","617660","617652","617651","617657","617656","617658","617662","617663","617659","617654","617655","617665","617664","617653"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2007-11-13","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"It is important to evaluate the health effects of low-dose-rate or low-dose radiation in combination with chemicals as humans are exposed to a variety of chemical agents. Here, we examined combined genotoxic effects of low-dose-rate radiation and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), the most carcinogenic tobacco-specific nitrosamine, in the lung of gpt delta transgenic mice. In this mouse model, base substitutions and deletions can be separately analyzed by gpt and Spi- selections, respectively. Female gpt delta mice were treated either with gamma-irradiation alone at a dose rate of 0.5, 1.0 or 1.5 mGy/h for 22 h/day for 31 days or its combination with NNK at a dose of 2 mg/mouse/day, i.p. for four consecutive days in the middle course of irradiation. In the gpt selection, the NNK treatments enhanced the mutation frequencies (MFs) significantly, but no obvious combined effects of gamma-irradiation were observable at any given radiation dose. In contrast, NNK treatments appeared to suppress the Spi- large deletions. In the Spi- selection, the MFs of deletions more than 1 kb in size increased in a dose-dependent manner. When NNK treatments were combined, the dose-response curve became bell-shaped where the MF at the highest radiation dose decreased substantially. These results suggest that NNK treatments may elicit an adaptive response that eliminates cells bearing radiation-induced double-strand breaks (DSBs) in DNA.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"New Nuclear Research Symposium \"Biological Responses to Low Dose Radiation\"","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ikeda, Megumi"}],"nameIdentifiers":[{"nameIdentifier":"617651","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Masumura, Kenichi"}],"nameIdentifiers":[{"nameIdentifier":"617652","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sakamoto, Yasuteru"}],"nameIdentifiers":[{"nameIdentifier":"617653","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Bing, Wang"}],"nameIdentifiers":[{"nameIdentifier":"617654","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nenoi, Mitsuru"}],"nameIdentifiers":[{"nameIdentifier":"617655","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sakuma, Keiko"}],"nameIdentifiers":[{"nameIdentifier":"617656","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hayata, Isamu"}],"nameIdentifiers":[{"nameIdentifier":"617657","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nohmi, Takehiko"}],"nameIdentifiers":[{"nameIdentifier":"617658","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"池田 恵","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"617659","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"増村 健一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"617660","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"坂元 康晃","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"617661","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"王 冰","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"617662","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"根井 充","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"617663","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"早田 勇","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"617664","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"能美 健彦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"617665","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Suppression of radiation-induced large deletions by combined treatments with a tobacco-specific nitrosamine in the lung of gpt delta transgenic mice","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Suppression of radiation-induced large deletions by combined treatments with a tobacco-specific nitrosamine in the lung of gpt delta transgenic mice"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-04-16"},"publish_date":"2008-04-16","publish_status":"0","recid":"62520","relation_version_is_last":true,"title":["Suppression of radiation-induced large deletions by combined treatments with a tobacco-specific nitrosamine in the lung of gpt delta transgenic mice"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:29:51.602881+00:00"}