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炭素線またはX線照射後のがん細胞における遺伝子発現プロファイルの差異
https://repo.qst.go.jp/records/62341
https://repo.qst.go.jp/records/623414498c669-cc0f-4817-b046-1ed14856dcd0
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2007-11-29 | |||||
| タイトル | ||||||
| タイトル | 炭素線またはX線照射後のがん細胞における遺伝子発現プロファイルの差異 | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
松本, 孔貴
× 松本, 孔貴× 松本 孔貴 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | [Purpose] To elucidate the molecular changes in response to carbon beams (C-ions) in melanoma. [Materials and Methods] We examined expression profiles of 6 melanoma cell lines exposed to C-ions or X-rays with 2 Gy using single-color microarrays. [Results] Twenty-two genes, including NFKBIA, responded in common to C-ions in all 6 cell lines, based on ANOVA filtering (P < 0.001). We found 173 genes that responded in common to C-ions in 4 cell lines. We identified many down-regulated genes (including the cell cycle–related genes CCNA2, CDCA8, CENPA, CRK7, ID1, KNTC2, TTK, and WEE1) that were more responsive to C-ions than X-rays. In contrast, most of the up-regulated genes (including the p53 target genes ATF3, BTG2, CDKN1A, GADD45A, SESN1, TNFRSF6, and TP53INP1) showed similar responses to C-ions and X-rays. C-ions induced G2/M arrest significantly more than X-rays at 30 h (P < 0.05). [Conclusion] Our findings suggest that down-regulation of gene expression plays a key role in the response to C-ions. Regulation of cell cycle–related genes and induction of prolonged G2/M arrest may be responsible for the extra sensitivity to C-ions, whereas p53–related genes may have similar roles in the sensitivities to both C-ions and X-rays. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 原子炉専門研究会 | |||||
| 発表年月日 | ||||||
| 日付 | 2007-09-29 | |||||
| 日付タイプ | Issued | |||||
