{"created":"2023-05-15T14:45:37.573056+00:00","id":62341,"links":{},"metadata":{"_buckets":{"deposit":"accf1890-572b-4e67-9dd3-fe5514603120"},"_deposit":{"created_by":1,"id":"62341","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"62341"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00062341","sets":["10:29"]},"author_link":["616230","616229"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2007-09-29","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"[Purpose] To elucidate the molecular changes in response to carbon beams (C-ions) in melanoma. \n[Materials and Methods] We examined expression profiles of 6 melanoma cell lines exposed to C-ions or X-rays with 2 Gy using single-color microarrays. \n[Results] Twenty-two genes, including NFKBIA, responded in common to C-ions in all 6 cell lines, based on ANOVA filtering (P < 0.001). We found 173 genes that responded in common to C-ions in 4 cell lines. We identified many down-regulated genes (including the cell cycle&#8211;related genes CCNA2, CDCA8, CENPA, CRK7, ID1, KNTC2, TTK, and WEE1) that were more responsive to C-ions than X-rays. In contrast, most of the up-regulated genes (including the p53 target genes ATF3, BTG2, CDKN1A, GADD45A, SESN1, TNFRSF6, and TP53INP1) showed similar responses to C-ions and X-rays. C-ions induced G2/M arrest significantly more than X-rays at 30 h (P < 0.05).\n[Conclusion] Our findings suggest that down-regulation of gene expression plays a key role in the response to C-ions. Regulation of cell cycle&#8211;related genes and induction of prolonged G2/M arrest may be responsible for the extra sensitivity to C-ions, whereas p53&#8211;related genes may have similar roles in the sensitivities to both C-ions and X-rays.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"原子炉専門研究会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"松本, 孔貴"}],"nameIdentifiers":[{"nameIdentifier":"616229","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"松本 孔貴","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"616230","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"炭素線またはX線照射後のがん細胞における遺伝子発現プロファイルの差異","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"炭素線またはX線照射後のがん細胞における遺伝子発現プロファイルの差異"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2007-11-29"},"publish_date":"2007-11-29","publish_status":"0","recid":"62341","relation_version_is_last":true,"title":["炭素線またはX線照射後のがん細胞における遺伝子発現プロファイルの差異"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:31:52.858957+00:00"}