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ラット精子形成細胞における粒子線の影響に関する研究(II)
https://repo.qst.go.jp/records/61778
https://repo.qst.go.jp/records/6177891557a47-d3b6-4fe7-a7b1-127b66370826
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2006-09-15 | |||||
| タイトル | ||||||
| タイトル | ラット精子形成細胞における粒子線の影響に関する研究(II) | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
王, 冰
× 王, 冰× 村上, 正弘× 笠井, 清美× 野島, 久美恵× 尚, 奕× 田中, 薫× 藤田, 和子× Ｈｅｒｖｅ, Ｃｏｆｆｉｇｎｙ× 早田, 勇× 王 冰× 村上 正弘× 笠井 清美× 野島 久美恵× 尚 奕× 田中 薫× 藤田 和子× 早田 勇 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Effects on gonads in prenatal male fetuses, and on the postnatal testicular development and reproductivity of male offspring were studied following exposure of pregnant Wistar rats to either accelerated carbon-ion beans with a linear energy transfer (LET) value of about 13 keV/mm or neon-ion beams with a LET value of about 30 keV/mm at a dose range from 0.1 Gy to 2.0 Gy on gestation day 15. Induction of apoptosis in fetal gonocytes was evaluated pathologically in male gonads. Mean number of pups, preweaning mortality, and the age for testis descent in offspring were examined. Testis weight and its ratio to body weight were measured on postnatal days 30, 60 and 90, respectively. Development of testicular tubules was analyzed histologically. In addition, in the male offspring, the successful mating rates with non-irradiated female rats, the mean number of pups descended, and the weaning rates of the pups were investigated. The effects of X-rays at 200 kVp estimated for the same biological end points were studied for comparison. For heavy ions, a dose of 2.0 Gy caused 100% preweaning mortality. For some endpoints, such as preweaning mortality, testis weight, and ratio of testis weight to body weight, significant alteration was observed in offspring prenatally received only 0.1 Gy of accelerated neon ions; while for the most endpoints regarding the effects from carbon ions or X rays, a significant alteration could be observed only when a dose was at 0.5 Gy or more. In this dose range, apoptosis in gonocytes of fetal gonads, of which the distribution was strongly clustered, was significantly induced in a dose-dependent manner with a peak at around 12 to 18 hr after irradiation; in the prenatally irradiated pups, statistical significances for increased prenatal death, delayed accomplishment in testis descent, low testis weight, changed ratios of testis weight to body weight, and increased malformed testicular seminiferous tubules were recorded. When the dose was at 1.0 Gy or 1.5 Gy, marked decrease in successful mating rates was also observed for the prenatally irradiated male rats with the non-irradiated female rats. On the other hand, for the animals descended from both the prenatally irradiated male rats and the non-irradiated female rats, significant increase in prenatal death and in preweaning mortality was scored when the father rats were prenatally irradiated with 0.5 Gy or more. These findings indicated that prenatal irradiations on gestation day 15 generally induced markedly detrimental effect on fetal development, postnatal testicular maturation and male reproductivity in rats, which was a dose and LET-related event. Investigations using HiCEP on radiation-induced gene expressions in fetal gonad tissues are in progress. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 平成17年度HIMAC共同利用研究成果発表会 | |||||
| 発表年月日 | ||||||
| 日付 | 2006-04-04 | |||||
| 日付タイプ | Issued | |||||
