{"created":"2023-05-15T14:45:12.474345+00:00","id":61778,"links":{},"metadata":{"_buckets":{"deposit":"7366c117-7ed4-4f1e-99b9-907d54d06f0e"},"_deposit":{"created_by":1,"id":"61778","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"61778"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00061778","sets":["10:29"]},"author_link":["611554","611544","611542","611546","611555","611551","611543","611549","611550","611545","611556","611541","611547","611552","611540","611553","611548"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2006-04-04","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Effects on gonads in prenatal male fetuses, and on the postnatal testicular\ndevelopment and reproductivity of male offspring were studied following\nexposure of pregnant Wistar rats to either accelerated carbon-ion beans with\na linear energy transfer (LET) value of about 13 keV/mm or neon-ion beams\nwith a LET value of about 30 keV/mm at a dose range from 0.1 Gy to 2.0 Gy on\ngestation day 15. Induction of apoptosis in fetal gonocytes was evaluated\npathologically in male gonads. Mean number of pups, preweaning mortality,\nand the age for testis descent in offspring were examined. Testis weight and\nits ratio to body weight were measured on postnatal days 30, 60 and 90,\nrespectively. Development of testicular tubules was analyzed histologically.\nIn addition, in the male offspring, the successful mating rates with\nnon-irradiated female rats, the mean number of pups descended, and the\nweaning rates of the pups were investigated. The effects of X-rays at 200\nkVp estimated for the same biological end points were studied for\ncomparison. For heavy ions, a dose of 2.0 Gy caused 100% preweaning\nmortality. For some endpoints, such as preweaning mortality, testis weight,\nand ratio of testis weight to body weight, significant alteration was\nobserved in offspring prenatally received only 0.1 Gy of accelerated neon\nions; while for the most endpoints regarding the effects from carbon ions or\nX rays, a significant alteration could be observed only when a dose was at\n0.5 Gy or more. In this dose range, apoptosis in gonocytes of fetal gonads,\nof which the distribution was strongly clustered, was significantly induced\nin a dose-dependent manner with a peak at around 12 to 18 hr after\nirradiation; in the prenatally irradiated pups, statistical significances\nfor increased prenatal death, delayed accomplishment in testis descent, low\ntestis weight, changed ratios of testis weight to body weight, and increased\nmalformed testicular seminiferous tubules were recorded. When the dose was\nat 1.0 Gy or 1.5 Gy, marked decrease in successful mating rates was also\nobserved for the prenatally irradiated male rats with the non-irradiated\nfemale rats. On the other hand, for the animals descended from both the\nprenatally irradiated male rats and the non-irradiated female rats,\nsignificant increase in prenatal death and in preweaning mortality was\nscored when the father rats were prenatally irradiated with 0.5 Gy or more.\nThese findings indicated that prenatal irradiations on gestation day 15\ngenerally induced markedly detrimental effect on fetal development,\npostnatal testicular maturation and male reproductivity in rats, which was a\ndose and LET-related event. Investigations using HiCEP on radiation-induced\ngene expressions in fetal gonad tissues are in progress.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"平成17年度HIMAC共同利用研究成果発表会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"王, 冰"}],"nameIdentifiers":[{"nameIdentifier":"611540","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"村上, 正弘"}],"nameIdentifiers":[{"nameIdentifier":"611541","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"笠井, 清美"}],"nameIdentifiers":[{"nameIdentifier":"611542","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"野島, 久美恵"}],"nameIdentifiers":[{"nameIdentifier":"611543","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"尚, 奕"}],"nameIdentifiers":[{"nameIdentifier":"611544","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田中, 薫"}],"nameIdentifiers":[{"nameIdentifier":"611545","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤田, 和子"}],"nameIdentifiers":[{"nameIdentifier":"611546","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ｈｅｒｖｅ, Ｃｏｆｆｉｇｎｙ"}],"nameIdentifiers":[{"nameIdentifier":"611547","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"早田, 勇"}],"nameIdentifiers":[{"nameIdentifier":"611548","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"王 冰","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"611549","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"村上 正弘","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"611550","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"笠井 清美","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"611551","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"野島 久美恵","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"611552","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"尚 奕","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"611553","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田中 薫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"611554","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤田 和子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"611555","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"早田 勇","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"611556","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"ラット精子形成細胞における粒子線の影響に関する研究(II)","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ラット精子形成細胞における粒子線の影響に関する研究(II)"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2006-09-15"},"publish_date":"2006-09-15","publish_status":"0","recid":"61778","relation_version_is_last":true,"title":["ラット精子形成細胞における粒子線の影響に関する研究(II)"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:38:24.575001+00:00"}