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DUAL-ISOTOPE SPECT USING 111In ANTI-TENASCIN-C ANTIBODY AND 99mTc-SESTAMIBI TO ASSESS DISEASE ACTIVITY OF MYOCARDITIS IN RATS
https://repo.qst.go.jp/records/61635
https://repo.qst.go.jp/records/6163530407ef3-e393-4058-a85e-7ff9f5733b0d
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2006-07-06 | |||||
| タイトル | ||||||
| タイトル | DUAL-ISOTOPE SPECT USING 111In ANTI-TENASCIN-C ANTIBODY AND 99mTc-SESTAMIBI TO ASSESS DISEASE ACTIVITY OF MYOCARDITIS IN RATS | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Odaka, Kenichi
× Odaka, Kenichi× Toyozaki, Tetsuya× Uehara, Tomoya× Arano, Yasushi× Yoshida, Katsuya× Sato, Mikio× Hasegawa, Hiroshi× Tadokoro, Hiroyuki× Yoshida, Kyoko× Yoshida, Toshimichi× Hiroe, Michiaki× Irie, Toshiaki× Tanada, Shuji× Komuro, Issei× 小高 謙一× 上原 知也× 荒野 泰× 吉田 勝哉× 佐藤 幹生× 長谷川 洋× 田所 裕之× 入江 俊章× 棚田 修二 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background: The identification of inflammatory infiltrates in endomyocardial biopsy specimens is necessary for the definite diagnosis of myocarditis, despite an invasive method. Expression of tenascin-C (TNC), one of the oligometric extracellular glycoproteins, is induced in myocardium during active stage of myocarditis. Therefore, TNC may be a molecular marker for disease activity in myocarditis. Methods: 111In-anti-TNC monoclonal antibody was injected intravenously to 10 experimental autoimmune myocarditis (EAM) rats and 10 control rats, and the biodistribution of this radiotracer was measured. Excised and sectioned hearts were stained with hematoxylin and eosin for histological analysis and were exposed to autoradiography. In vivo SPECT imaging was simultaneously performed with 111In-anti-TNC and 99mTc-Sestamibi. The SPECT system consisted of a 3-headed gamma-camera equipped with 1.0-mm pinhole collimators. Results: Average myocardial radioactivity was significantly higher in EAM rats than controls (2.39+/-0.17 %injected-dose/g vs. 0.32+/-0.03, p < 0.01). By autoradiography, high radioactivities were observed in the regions identical with inflammation in EAM rats. SPECT imaging in EAM rats clearly showed the focal myocardial uptake of 111In-anti-TNC, which is complementary to perfusion image. Conclusions: The present study indicated a high ability of anti-TNC antibody to localize sites of inflammation in the heart by ex-vivo and in-vivo imaging. Radiolabeled anti-TNC may be useful for the noninvasive diagnosis of myocarditis. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 50th Annual Meeting of Society of Nuclear Medicine | |||||
| 発表年月日 | ||||||
| 日付 | 2003-06-25 | |||||
| 日付タイプ | Issued | |||||
