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IMAGING ATHEROSCLEROTIC PLAQUE IN OLD AND HYPERLIPIDEMIC RABBITS USING 18F-FDG AND PET
https://repo.qst.go.jp/records/61456
https://repo.qst.go.jp/records/61456c541d800-ec50-4138-8fa3-2a09d26ef7d5
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2006-06-13 | |||||
| タイトル | ||||||
| タイトル | IMAGING ATHEROSCLEROTIC PLAQUE IN OLD AND HYPERLIPIDEMIC RABBITS USING 18F-FDG AND PET | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Odaka, Kenichi
× Odaka, Kenichi× Yoshida, Katsuya× Tadokoro, Hiroyuki× Suzuki, Kazutoshi× Irie, Toshiaki× Tanada, Shuji× Komuro, Issei× 小高 謙一× 吉田 勝哉× 田所 裕之× 鈴木 和年× 入江 俊章× 棚田 修二 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background: Atherosclerotic plaque containing macrophage-rich areas, has a high risk of rupture. The uptake of glucose analogue 18F-FDG in the atherosclerotic lesions correlates with the density of macrophages in vitro hyperlipidemic animal model. However, physiologic changes of senescence may also cause arterial wall FDG uptake. Therefore, we examined whether FDG-PET can identify the macrophage-rich areas of plaque in old and hyperlipidemic rabbits. Methods: 18F-FDG (6 mCi) was injected intravenously to old rabbits including 1 Watanabe heritable hyperlipidemic (WHHL) rabbit (5.5 y.o.) and 4 Japanese white (JW) rabbits (5.2 y.o.). In vivo PET imaging was performed from 30 to 60min after FDG injection. Excised and sectioned abdominal aortas were exposed to autoradiography and stained with oil-red O for the maker of lipids. Results: Only a WHHL rabbit but no JW rabbit showed a remarkable uptake of 18F-FDG in abdominal aorta by PET. Excised and sectioned abdominal aorta of WHHL rabbit had diffuse striated lipids stained with oil-red O in vascular lumen, despite little stain in vascular lumen of JW rabbits. By autoradiography, 5 times higher radioactivity than referential low count area, were observed in the small part of diffuse striated lipids corresponding to severe stenosis in WHHL rabbit. Conclusions: 18F-FDG identified the macrophage-rich plaque in the abdominal aorta of hyperlipidemic rabbit by ex-vivo and in-vivo imaging. FDG-PET may be useful to predict the future plaque rupture in aged and hyperlipidemic subjects. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 50th Annual Meeting of Society of Nuclear Medicine | |||||
| 発表年月日 | ||||||
| 日付 | 2003-06-25 | |||||
| 日付タイプ | Issued | |||||
