@misc{oai:repo.qst.go.jp:00061456,
 author = {Odaka, Kenichi and Yoshida, Katsuya and Tadokoro, Hiroyuki and Suzuki, Kazutoshi and Irie, Toshiaki and Tanada, Shuji and Komuro, Issei and 小高 謙一 and 吉田 勝哉 and 田所 裕之 and 鈴木 和年 and 入江 俊章 and 棚田 修二},
 month = {Jun},
 note = {Background: Atherosclerotic plaque containing macrophage-rich areas, has a high risk of rupture.  The uptake of glucose analogue 18F-FDG in the atherosclerotic lesions correlates with the density of macrophages in vitro hyperlipidemic animal model.  However, physiologic changes of senescence may also cause arterial wall FDG uptake.  Therefore, we examined whether FDG-PET can identify the macrophage-rich areas of plaque in old and hyperlipidemic rabbits.  
Methods: 18F-FDG (6 mCi) was injected intravenously to old rabbits including 1 Watanabe heritable hyperlipidemic (WHHL) rabbit (5.5 y.o.) and 4 Japanese white (JW) rabbits (5.2 y.o.).  In vivo PET imaging was performed from 30 to 60min after FDG injection.  Excised and sectioned abdominal aortas were exposed to autoradiography and stained with oil-red O for the maker of lipids.  Results: Only a WHHL rabbit but no JW rabbit showed a remarkable uptake of 18F-FDG in abdominal aorta by PET.  Excised and sectioned abdominal aorta of WHHL rabbit had diffuse striated lipids stained with oil-red O in vascular lumen, despite little stain in vascular lumen of JW rabbits.  By autoradiography, 5 times higher radioactivity than referential low count area, were observed in the small part of diffuse striated lipids corresponding to severe stenosis in WHHL rabbit.  Conclusions: 18F-FDG identified the macrophage-rich plaque in the abdominal aorta of hyperlipidemic rabbit by ex-vivo and in-vivo imaging.  FDG-PET may be useful to predict the future plaque rupture in aged and hyperlipidemic subjects., 50th Annual Meeting of Society of Nuclear Medicine},
 title = {IMAGING ATHEROSCLEROTIC PLAQUE IN OLD AND HYPERLIPIDEMIC RABBITS USING 18F-FDG AND PET},
 year = {2003}
}