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胸腺リンパ腫における放射線とエチルニトロソウレアの複合影響
https://repo.qst.go.jp/records/60701
https://repo.qst.go.jp/records/60701de781e8d-1a10-4fda-840a-37e7c7353146
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2004-11-29 | |||||
| タイトル | ||||||
| タイトル | 胸腺リンパ腫における放射線とエチルニトロソウレアの複合影響 | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
柿沼, 志津子
× 柿沼, 志津子× 甘崎, 佳子× 高田, 真由美× 渡辺, 健一× 桑原, 義和× 矢島, 香代子× 今岡, 達彦× 西村, まゆみ× 島田, 義也× 柿沼 志津子× 甘崎 佳子× 高田 真由美× 渡辺 健一× 桑原 義和× 矢島 香代子× 今岡 達彦× 西村 まゆみ× 島田 義也 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | We are living in the environment with numerous natural and man-made chemicals that are cancer-initiating and promoting potentials. For this reason, radiation carcinogenesis in human is considered as a result of interaction with these factors. But, the quantitative assessment and mechanistic understanding of combined effects of radiation and chemical carcinogens are still insufficient. Murine thymic lymphoma (TL), which are reproducibly induced by radiation and chemicals, has been utilized as a good model for elucidating cellular and molecular mechanism of human lymphocytic leukemia. The aim of this study are (i) to determine the mode of TL induction by combined treatment of X-rays and N-ethyl-N-nitrosourea (ENU), and (ii) to compare the molecular alterations among the TLs induced after X-rays, ENU or combined treatment. The dose-response curve of TLs after single treatment of X-rays and ENU was sigmoidal and linear, both with threshold dose, respectively. For combined treatment, synergistic effect was obvious for high dose radiation, while the effect was marginal for low or threshold dose radiation. It was interesting that there still existed threshold for X-rays in the combination with ENU. The molecular changes in the TLs induced by combined treatment were similar to those by ENU. It is suggested, therefore, that radiation acts as promoter or conditioner for ENU-induced lymphomagenesis. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第47回日本放射線影響学会大会 | |||||
| 発表年月日 | ||||||
| 日付 | 2004-11-27 | |||||
| 日付タイプ | Issued | |||||
