@misc{oai:repo.qst.go.jp:00060701,
 author = {柿沼, 志津子 and 甘崎, 佳子 and 高田, 真由美 and 渡辺, 健一 and 桑原, 義和 and 矢島, 香代子 and 今岡, 達彦 and 西村, まゆみ and 島田, 義也 and 柿沼 志津子 and 甘崎 佳子 and 高田 真由美 and 渡辺 健一 and 桑原 義和 and 矢島 香代子 and 今岡 達彦 and 西村 まゆみ and 島田 義也},
 month = {Nov},
 note = {We are living in the environment with numerous natural and man-made chemicals that are cancer-initiating and promoting potentials. For this reason, radiation carcinogenesis in human is considered as a result of interaction with these factors. But, the quantitative assessment and mechanistic understanding of combined effects of radiation and chemical carcinogens are still insufficient. Murine thymic lymphoma (TL), which are reproducibly induced by radiation and chemicals, has been utilized as a good model for elucidating cellular and molecular mechanism of human lymphocytic leukemia. The aim of this study are (i) to determine the mode of TL induction by combined treatment of X-rays and N-ethyl-N-nitrosourea (ENU), and (ii) to compare the molecular alterations among the TLs induced after X-rays, ENU or combined treatment.  The dose-response curve of TLs after single treatment of X-rays and ENU was sigmoidal and linear, both with threshold dose, respectively.  For combined treatment, synergistic effect was obvious for high dose radiation, while the effect was marginal for low or threshold dose radiation.  It was interesting that there still existed threshold for X-rays in the combination with ENU.  The molecular changes in the TLs induced by combined treatment were similar to those by ENU.  It is suggested, therefore, that radiation acts as promoter or conditioner for ENU-induced lymphomagenesis., 第47回日本放射線影響学会大会},
 title = {胸腺リンパ腫における放射線とエチルニトロソウレアの複合影響},
 year = {2004}
}