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Fast He2+ and C6+ Ion Irradiation of DNA Loaded With Platinum Containing Molecules.
https://repo.qst.go.jp/records/60676
https://repo.qst.go.jp/records/6067623d7728b-15a0-4e9a-ac49-3001a3ae8cf8
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2004-11-22 | |||||
| タイトル | ||||||
| タイトル | Fast He2+ and C6+ Ion Irradiation of DNA Loaded With Platinum Containing Molecules. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Le, Sech Claude
× Le, Sech Claude× Usami, Noriko× Furusawa, Yoshiya× Kobayashi, Katsumi× et.al× ルシェッ クロード× 宇佐美 徳子× 古澤 佳也× 小林 克己 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Complexes of plasmid-DNA and dichloroterpyridine platinum (PtTC) molecules are irradiated with fast He2+ and C6+ ions. The results show a significant increase in DNA strand breaks when platinum is present, suggesting a radio-sensitization. The increase in DNA damages is attributed to inner-shell ionization of a platinum atom by secondary electrons, emitted along the He2+ tracks and followed by an Auger effect. Additional experiments, performed in presence of dimethyl sulfoxide (DMSO), a free radical scavenger, indicate that a large part of the DNA damages are mediated by a free radical attack. These findings suggest that the Auger effect, following the ionization of the platinum atom by secondary electrons, leads significantly to radiolysis of the surrounding water; OH free radical clusters are created close to the platinum atom and therefore close to the DNA, inducing efficiently DNA strand breaks. The respective contribution of scavengeable and non-scavengeable effects is quantitatively evaluated. A discussion of the contribution of the Auger effect to scavengeable and non-scavengeable effects is also presented. Considerations of Auger effects in the other atoms constituing the DNA (P, O, C, N) are made. The role of the K shell ionisation in these atoms is investigated in the light of the results obtained when platinum atoms are present. The present results are qualitatively similar to those obtained when soft X-rays photons are used to irradiate such DNA complexes. They suggest a possible application to protocols associating protontherapy (hadrontherapy) and chemotherapy with molecules containing high-Z atoms like cis-dichloro-diamino platin (cis DDP). | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Research and Applications in Radiobiology with Swift Ions | |||||
| 発表年月日 | ||||||
| 日付 | 2004-10-30 | |||||
| 日付タイプ | Issued | |||||
