{"created":"2023-05-15T14:44:22.679513+00:00","id":60676,"links":{},"metadata":{"_buckets":{"deposit":"47a0e2dc-da31-4ea7-ab6e-ba81d824689f"},"_deposit":{"created_by":1,"id":"60676","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"60676"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00060676","sets":["10:29"]},"author_link":["601688","601682","601689","601690","601687","601685","601684","601686","601683"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2004-10-30","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Complexes of plasmid-DNA and dichloroterpyridine platinum (PtTC) molecules are irradiated with fast He2+ and C6+ ions. The results show a significant increase in DNA strand breaks when platinum is present, suggesting a radio-sensitization. The increase in DNA damages is attributed to inner-shell ionization of a platinum atom by secondary electrons, emitted along the He2+ tracks and followed by an Auger effect. Additional experiments, performed in presence of dimethyl sulfoxide (DMSO), a free radical scavenger, indicate that a large part of the DNA damages are mediated by a free radical attack. These findings suggest that the Auger effect, following the ionization of the platinum atom by secondary electrons, leads significantly to radiolysis of the surrounding water; OH free radical clusters are created close to the platinum atom and therefore close to the DNA, inducing efficiently DNA strand breaks. The respective contribution of scavengeable and non-scavengeable effects is quantitatively evaluated. A discussion of the contribution of the Auger effect to scavengeable and non-scavengeable effects is also presented. Considerations of Auger effects in the other atoms constituing the DNA (P, O, C, N) are made. The role of the K shell ionisation in these atoms is investigated in the light of the results obtained when platinum atoms are present.   The present results are qualitatively similar to those obtained when soft X-rays photons are used to irradiate such DNA complexes. They suggest a possible application to protocols associating protontherapy (hadrontherapy) and chemotherapy with molecules containing high-Z atoms like cis-dichloro-diamino platin (cis DDP).","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"Research and Applications in Radiobiology with Swift Ions","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Le, Sech Claude"}],"nameIdentifiers":[{"nameIdentifier":"601682","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Usami, Noriko"}],"nameIdentifiers":[{"nameIdentifier":"601683","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Furusawa, Yoshiya"}],"nameIdentifiers":[{"nameIdentifier":"601684","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kobayashi, Katsumi"}],"nameIdentifiers":[{"nameIdentifier":"601685","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"et.al"}],"nameIdentifiers":[{"nameIdentifier":"601686","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"ルシェッ クロード","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"601687","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"宇佐美 徳子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"601688","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"古澤 佳也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"601689","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小林 克己","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"601690","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Fast He2+ and C6+ Ion Irradiation of DNA Loaded With Platinum Containing Molecules.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Fast He2+ and C6+ Ion Irradiation of DNA Loaded With Platinum Containing Molecules."}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2004-11-22"},"publish_date":"2004-11-22","publish_status":"0","recid":"60676","relation_version_is_last":true,"title":["Fast He2+ and C6+ Ion Irradiation of DNA Loaded With Platinum Containing Molecules."],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:51:03.623053+00:00"}