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Combination of carbon-beam and X-ray: biologically synergistic or additive?
https://repo.qst.go.jp/records/60530
https://repo.qst.go.jp/records/6053003478cfc-5a25-4d32-a147-b80a21b19444
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2004-09-08 | |||||
| タイトル | ||||||
| タイトル | Combination of carbon-beam and X-ray: biologically synergistic or additive? | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
出水, 祐介
× 出水, 祐介× 香川, 一史× 江島, 泰生× 西村, 英輝× 佐々木, 良平× 副島, 俊典× 古澤, 佳也× 菱川, 良夫× 杉村, 和朗× 出水 祐介× 香川 一史× 江島 泰生× 西村 英輝× 佐々木 良平× 古澤 佳也× 菱川 良夫× 杉村 和朗 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Purpose: To investigate the biological effects of combining carbon-beam and X-ray in vitro. Methods and Materials: Cultured cells from human salivary gland cancer (HSGc-C5 cells) were irradiatied with a single source of carbon-beam (320 MeV/nucleon) or X-ray (4 MV), or with a combination of the two. Cell survivals were evaluated by clonogenic assay and survival curves were fitted using the LQ model. Sensitivity with long interval (72 hours) irradiation was also assessed. Theoretical survival curve of the combination was proposed with estimation of the cytotoxicity using actual carbon-beam and X-ray curves. Results: Carbon-beam showed the strongest effect, X-ray the weakest, and the combination intermediate for physical doses. The sequence of combination of carbon-beam and X-ray did not affect clonogenic survival. For biological equivalent doses, carbon-beam, X-ray, and the combination of both had equal effects. The theoretical survival curves corresponded well to the actual curves of the combination. The same results were observed with long interval irradiation. Conclusions: The biological effects of combining carbon-beam and X-ray were additive but not synergistic in vitro. These results may provide important and novel information about the combination of carbon-beam and X-ray irradiation. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第63回日本医学放射線学会学術発表会 | |||||
| 発表年月日 | ||||||
| 日付 | 2004-04-10 | |||||
| 日付タイプ | Issued | |||||
