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Toxicities and Effects of CBMIDA and EHBP on Removal of Intramuscularly Injected Depleted Uranium in Rats
https://repo.qst.go.jp/records/60486
https://repo.qst.go.jp/records/60486b39f1a29-a8d9-4862-a4ff-2bc1cba3ef56
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2004-07-20 | |||||
| タイトル | ||||||
| タイトル | Toxicities and Effects of CBMIDA and EHBP on Removal of Intramuscularly Injected Depleted Uranium in Rats | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Fukuda, Satoshi
× Fukuda, Satoshi× Iida, Haruzo× Yan, Xueming× Xie, Yuyuan× 福田 俊× 飯田 治三× 厳 雪銘 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The toxicities and effects of CBMIDA and EHBP on removal of depleted uranium (DU) by intramuscular injection in the femoral muscles as simulated wounds in rats were examined in Experiment I~III. Male rats, 8 weeks old, were used. Experiment I: Rats were injected intramuscularly with 7.9, 15,8, 31.5, 63 and 126mg/kg depleted uranium. All rats died from 3~7 days after injection. The concentrations of DU in the kidneys were 8.4-16.6% of injected doses (r=0.997). In the rats injected with 63, 126 mg/kg, the urinary excretion of DU was observed at first day, and the feces excretion was for 2 days, but did not observed at third day. Total amount of excreted DU for 3 days were 3.4 % and 4.9% of the injected doses. Experiment II: Rats were injected with 63 mg/kg DU, and then killed 1, 3, 6 and 24 hours to know the retention. The concentration of DU decreased rapidly in the serum, while increased in the kidneys and liver until 6 hours after injection, and continued to increase in the femur until 24 hours. Experiment III: Forty rats were injected intramuscularly with 2mg/kg DU, and divide into four groups; G1) non-treated, G2) 0.48mg/kg CBMIDA, G3) 0.24mg/kg CBMIDA, and G4) 10mg/kg EHBP. The chelating agents were administered intraperitoneally once everyday for 28 days. Rats died for firs 10 days in the G1~3, and for 14 days in the G4. The survival rates at the end of experiment were 20% in the G1, 40% in the G2, 80% in the G3 and 50% in the G4. The rapid decreases in body weights were observed for first 10 days. The concentrations of DU in the organs in the G2-4 were observed. Abnormal values in blood examination were observed in G1-4, and BUN and creatinine were elevated. The results indicated that the lethal dose of DU by intramuscular injection was toxic over 7.9 mg/kg, and the DU retained rapidly in the kidneys, a target organ, and did not excreted after 2 days. CBMIDA and EHBP were effective to increase survival rates by removing DU in the kidneys and other organs. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 7th International Symposium on Chelating Agents in Biomedicine Toxicology and Therapeutics | |||||
| 発表年月日 | ||||||
| 日付 | 2004-07-11 | |||||
| 日付タイプ | Issued | |||||
