{"created":"2023-05-15T14:44:14.211154+00:00","id":60486,"links":{},"metadata":{"_buckets":{"deposit":"05c58f36-7e41-4923-96cb-be01b3067b2c"},"_deposit":{"created_by":1,"id":"60486","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"60486"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00060486","sets":["10:29"]},"author_link":["600473","600469","600474","600471","600472","600475","600470"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2004-07-11","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The toxicities and effects of CBMIDA and EHBP on removal of depleted uranium (DU) by intramuscular injection in the femoral muscles as simulated wounds in rats were examined in Experiment I~III. Male rats, 8 weeks old, were used. Experiment I: Rats were injected intramuscularly with 7.9, 15,8, 31.5, 63 and 126mg/kg depleted uranium. All rats died from 3~7 days after injection. The concentrations of DU in the kidneys were 8.4-16.6% of injected doses (r=0.997). In the rats injected with 63, 126 mg/kg, the urinary excretion of DU was observed at first day, and the feces excretion was for 2 days, but did not observed at third day. Total amount of excreted DU for 3 days were 3.4 % and 4.9% of the injected doses.  \n   Experiment II: Rats were injected with 63 mg/kg DU, and then killed 1, 3, 6 and 24 hours to know the retention. The concentration of DU decreased rapidly in the serum, while increased in the kidneys and liver until 6 hours after injection, and continued to increase in the femur until 24 hours. \n    Experiment III: Forty rats were injected intramuscularly with 2mg/kg DU, and divide into four groups; G1) non-treated, G2) 0.48mg/kg CBMIDA, G3) 0.24mg/kg CBMIDA, and G4) 10mg/kg EHBP. The chelating agents were administered intraperitoneally once everyday for 28 days. Rats died for firs 10 days in the G1~3, and for 14 days in the G4. The survival rates at the end of experiment were 20% in the G1, 40% in the G2, 80% in the G3 and 50% in the G4.  The rapid decreases in body weights were observed for first 10 days. The concentrations of DU in the organs in the G2-4 were observed. Abnormal values in blood examination were observed in G1-4, and BUN and creatinine were elevated. \n    The results indicated that the lethal dose of DU by intramuscular injection was toxic over 7.9 mg/kg, and the DU retained rapidly in the kidneys, a target organ, and did not excreted after 2 days. CBMIDA and EHBP were effective to increase survival rates by removing DU in the kidneys and other organs.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"7th International Symposium on Chelating Agents in Biomedicine Toxicology and Therapeutics","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Fukuda, Satoshi"}],"nameIdentifiers":[{"nameIdentifier":"600469","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Iida, Haruzo"}],"nameIdentifiers":[{"nameIdentifier":"600470","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yan, Xueming"}],"nameIdentifiers":[{"nameIdentifier":"600471","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Xie, Yuyuan"}],"nameIdentifiers":[{"nameIdentifier":"600472","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"福田 俊","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"600473","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"飯田 治三","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"600474","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"厳 雪銘","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"600475","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Toxicities and Effects of CBMIDA and EHBP on Removal of Intramuscularly Injected Depleted Uranium in Rats","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Toxicities and Effects of CBMIDA and EHBP on Removal of Intramuscularly Injected Depleted Uranium in Rats"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2004-07-20"},"publish_date":"2004-07-20","publish_status":"0","recid":"60486","relation_version_is_last":true,"title":["Toxicities and Effects of CBMIDA and EHBP on Removal of Intramuscularly Injected Depleted Uranium in Rats"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:53:14.388316+00:00"}