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Radiation-Induced Teratogenetic Effect and Adaptive Response in Late Organogenesis in Mice
https://repo.qst.go.jp/records/60401
https://repo.qst.go.jp/records/60401516ef157-6e0b-456e-92de-47186ac5e0cb
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2004-06-04 | |||||
| タイトル | ||||||
| タイトル | Radiation-Induced Teratogenetic Effect and Adaptive Response in Late Organogenesis in Mice | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Bing, Wang
× Bing, Wang× Ohyama, Harumi× Tanaka, Kaoru× Morimoto, Yasuko× Aizawa, Shirou× Yukawa, Osami× Hayata, Isamu× 王 冰× 大山 ハルミ× 田中 薫× 森本 泰子× 相澤 志郎× 湯川 修身× 早田 勇 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The limb developing system is a suitable model to study the teratogenetic effect of radiation in fetal mice. We found that radiation-induced apoptosis in the predigital regions of fetal limb buds was responsible for digital defects. In ICR and C57BL/6J mice, and C57BL/6J mice with different Trp53 gene status susceptibility to the radiation-induced apoptosis and digital defects was depending on the strain as well as Trp53 gene status and radiation dose. C57BL/6J mice were more radiosensitive than ICR mice. Trp53 wild-type C57BL/6J mice appeared to be the most radiosensitive and Trp53 knockout C57BL/6J mice the most radioresistant. An adaptive response (reduction of both fetal death and malformation) was demonstrated in fetal mice induced by priming low dose radiation prior to a high dose irradiation. Suppression of the digital defects was correlated to the inhibition of apoptosis. The priming dose was mouse strain-related. Both Trp53 alleles were essential for induction of the adaptive response. Furthermore, existence of the dose-rate effect was verified in both radiation-induced teratogenetic effect and adaptive response. The results indicate that Trp53-dependent apoptosis mediates radiation-induced digital defects and the Trp53 involves in the adaptive response in late organogenesis. Radiation-induced teratogenetic effect and adaptive response are due to a complex interplay between dose, dose rate and animal factors such as the strain, developmental stage, and gene background. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | The Fifth Japan-France Workshop on Radiobiology and Medical Imaging | |||||
| 発表年月日 | ||||||
| 日付 | 2004-06-04 | |||||
| 日付タイプ | Issued | |||||
