{"created":"2023-05-15T14:44:10.415097+00:00","id":60401,"links":{},"metadata":{"_buckets":{"deposit":"f963dd1b-e4bd-46f0-9d52-8aae630aaa21"},"_deposit":{"created_by":1,"id":"60401","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"60401"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00060401","sets":["10:29"]},"author_link":["599777","599775","599786","599783","599784","599781","599782","599780","599774","599779","599776","599787","599785","599778"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2004-06-04","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The limb developing system is a suitable model to study the teratogenetic effect of radiation in fetal mice. We found that radiation-induced apoptosis in the predigital regions of fetal limb buds was responsible for digital defects. In ICR and C57BL/6J mice, and C57BL/6J mice with different Trp53 gene status susceptibility to the radiation-induced apoptosis and digital defects was depending on the strain as well as Trp53 gene status and radiation dose. C57BL/6J mice were more radiosensitive than ICR mice. Trp53 wild-type C57BL/6J mice appeared to be the most radiosensitive and Trp53 knockout C57BL/6J mice the most radioresistant. An adaptive response (reduction of both fetal death and malformation) was demonstrated in fetal mice induced by priming low dose radiation prior to a high dose irradiation. Suppression of the digital defects was correlated to the inhibition of apoptosis. The priming dose was mouse strain-related. Both Trp53 alleles were essential for induction of the adaptive response. Furthermore, existence of the dose-rate effect was verified in both radiation-induced teratogenetic effect and adaptive response. The results indicate that Trp53-dependent apoptosis mediates radiation-induced digital defects and the Trp53 involves in the adaptive response in late organogenesis. Radiation-induced teratogenetic effect and adaptive response are due to a complex interplay between dose, dose rate and animal factors such as the strain, developmental stage, and gene background.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"The Fifth Japan-France Workshop on Radiobiology and Medical Imaging","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Bing, Wang"}],"nameIdentifiers":[{"nameIdentifier":"599774","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ohyama, Harumi"}],"nameIdentifiers":[{"nameIdentifier":"599775","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tanaka, Kaoru"}],"nameIdentifiers":[{"nameIdentifier":"599776","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Morimoto, Yasuko"}],"nameIdentifiers":[{"nameIdentifier":"599777","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Aizawa, Shirou"}],"nameIdentifiers":[{"nameIdentifier":"599778","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yukawa, Osami"}],"nameIdentifiers":[{"nameIdentifier":"599779","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hayata, Isamu"}],"nameIdentifiers":[{"nameIdentifier":"599780","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"王 冰","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"599781","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大山 ハルミ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"599782","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田中 薫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"599783","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"森本 泰子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"599784","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"相澤 志郎","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"599785","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"湯川 修身","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"599786","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"早田 勇","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"599787","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Radiation-Induced Teratogenetic Effect and Adaptive Response in Late Organogenesis in Mice","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Radiation-Induced Teratogenetic Effect and Adaptive Response in Late Organogenesis in Mice"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2004-06-04"},"publish_date":"2004-06-04","publish_status":"0","recid":"60401","relation_version_is_last":true,"title":["Radiation-Induced Teratogenetic Effect and Adaptive Response in Late Organogenesis in Mice"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:54:09.603177+00:00"}