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重粒子による胸腺リンパ腫の発症とそのメカニズムの分子生物学的研究
https://repo.qst.go.jp/records/59929
https://repo.qst.go.jp/records/599292f8f2264-de71-4019-bf8f-b17677e6af59
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2003-09-01 | |||||
| タイトル | ||||||
| タイトル | 重粒子による胸腺リンパ腫の発症とそのメカニズムの分子生物学的研究 | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
柿沼, 志津子
× 柿沼, 志津子× 野島, 久美恵× 物部, 真奈美× 島田, 義也× 西村, まゆみ× 石原, 弘× 田中, 泉× 柿沼 志津子× 野島 久美恵× 物部 真奈美× 島田 義也× 西村 まゆみ× 石原 弘× 田中 泉 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Biological effects of heavy ions have been extensively investigated using HIMAC synchrotron. One of major concern about heavy particles is its carcinogenic potential. However, the data are still scanty. We investigated the induction and cellular and molecular characteristics of thymic lymphomas (TLs) of B6C3F1 mice after exposure to carbon-ions and X-rays. The incidence of and latent period for the induction of TLs were similar between two types of TLs, although the size was much smaller for carbon-ion-induced TLs. FACS analysis revealed little difference in the surface expression of T-cell differentiation antigens. Molecular analysis indicated that high frequency of loss of heterzygosity (LOH) was found on chromosomes 4, 11, 12 and 19 in both TLs. However, the frequency was much higher in chromosome 11 and smaller in chromosome 12 in carbon-ion-induced TLs compared to X-ray-induced TLs. These results suggest mechanistic differences between carbon-ion- and X-ray-induced lymphomagenesis. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 平成14年度放射線医学総合研究所重粒子線がん治療装置等共同利用研究発表会 | |||||
| 発表年月日 | ||||||
| 日付 | 2003-04-08 | |||||
| 日付タイプ | Issued | |||||
