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マウス大脳皮質層構築に低線量放射線照射が与える影響
https://repo.qst.go.jp/records/59594
https://repo.qst.go.jp/records/595946d2872d3-b6ef-4edc-832e-fc1b78cd22a3
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2003-03-16 | |||||
| タイトル | ||||||
| タイトル | マウス大脳皮質層構築に低線量放射線照射が与える影響 | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
矢追, 毅
× 矢追, 毅× 野島, 久美恵× 伏木, 信次× 矢追 毅× 野島 久美恵× 伏木 信次 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Prenatal exposure to ionizing radiation of low doses in rodents induces deceleration of reuronal migration during cortical histogenesis, and results in desorganized cortical architecture in maure brain. On the contrary, exposure to carbon beams during fetal period mainly affects cell survival. However, the molecular mechanisms underlying such difference in the effects between exposure to carbon beams and exposure to X-rays remain unknown. We have attemped to elucidate whether the changes of gene expression after exposure to heavy ions differ from those after X-rays in fetal brains. Approximatately 13,000 cDNA species have been scanned and it turned out that more than twenty genes among the genes scanned were differentially expressed between X-irradiated embryos and non-irradiated ones. One of the genes showing up-regulation was Rab6A. Expression of these genes was compared between brains exposed to carbon beams and those to X-ray, the changing pattern was different. We identified the genes as candidates for the migration-associated genes. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第２５回日本神経科学・第４５回日本神経化学合同大会 | |||||
| 発表年月日 | ||||||
| 日付 | 2002-07-07 | |||||
| 日付タイプ | Issued | |||||
