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Does DPUI for inhaled actinide oxides actually reflect the risk of malignant lung tumor induction?
https://repo.qst.go.jp/records/59475
https://repo.qst.go.jp/records/5947586ee5ab8-77ea-483a-b0d8-d15769c6a5c1
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2002-12-13 | |||||
| タイトル | ||||||
| タイトル | Does DPUI for inhaled actinide oxides actually reflect the risk of malignant lung tumor induction? | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Fritsch, Paul
× Fritsch, Paul× Dudoignon, Nicolas× Guillet, Kristel× Oghiso, Yoichi× Paul, Morlier Jean× 小木曽 洋一 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The aim of this study was to compare lung tumour incidence measured in rats after inhalation exposure to aerosols containing alpha emitters which have different physico-chemical properties. Aerosols of radon and radon progeny, uranium ore dust, Np02, Pu02 or Cm203 were considered for inter-comparison with similar or different particle sizes. Dose-effect relationships for malignant lung tumour frequency appear linear up to a few Gy and then become infra linear at higher doses delivered to the lungs. The initial slope reflects the risk of lung tumour induction. The highest slopes of incidence were observed for radon and uranium ore dust (about 20%Gy-1) for which the most homogeneous alpha dose distribution to the lungs is expected. In a general trend, increasing the alpha activity of deposited particles (higher specific activity of constitutive radioisotopes or larger particle size) decreases the risk. The comparison of the reported data, shows that the risk per Gy at low doses (as well as DPUI) could vary over 1 order of magnitude depending on the physico-chemical properties of the aerosols. Mechanisms involved in the risk variation are discussed. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Workshop on Internal Doismetry of Radionuclides | |||||
| 発表年月日 | ||||||
| 日付 | 2002-09-12 | |||||
| 日付タイプ | Issued | |||||
