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Evaluation of a new biodosimetry based on scoring drug-induced prematurely condensed ring chromosome in the criticality cases in Tokai-mura
https://repo.qst.go.jp/records/59377
https://repo.qst.go.jp/records/59377bbef5d99-c25e-4844-b6da-b5430fafddcd
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2002-08-06 | |||||
| タイトル | ||||||
| タイトル | Evaluation of a new biodosimetry based on scoring drug-induced prematurely condensed ring chromosome in the criticality cases in Tokai-mura | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Hayata, Isamu
× Hayata, Isamu× 早田 勇 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The scoring of chromosome aberrations in human lymphocytes provides the most sensitive and reliable method in biodosimetry of radiation. The upper limit of the dose estimation by calculation with the linear-quadratic formula of dicentric and ring chromosomes (Dic and Ring) in conventional metaphase analysis is equivalent to a whole-body dose of 8 Gy gamma-rays (1). Furthermore, after high dose exposure (>5-10 Gy), the number of lymphocytes is reduced and the cell cycle is delayed to reach the metaphase. Therefore, it becomes difficult to estimate such high doses as over 8 Gy. In Tokai-mura criticality accident that occurred on September 30, 1999, three workers on the site were severely exposed to neuron and gamma-rays. The drastically reduced number of the lymphocytes indicated that the whole-body dose of radiation that they had been exposed to was unprecedentedly high. A new biodosimetry based on scoring drug-induced prematurely condensed ring chromosomes (PCC-R) that we developed just before the accident was applied to these cases (2). To evaluate this new biodosimetry, we compared the PCC-R data with those of Dic and Ring analysis. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 放射線生物学とイメージングに関する第4回日仏ワークショップ | |||||
| 発表年月日 | ||||||
| 日付 | 2002-06-27 | |||||
| 日付タイプ | Issued | |||||
