WEKO3
アイテム
Molecular Technology
https://repo.qst.go.jp/records/58918
https://repo.qst.go.jp/records/589187c8df9b3-3f23-4380-9ed9-3f99557e7758
| Item type | 一般雑誌記事 / Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-12-17 | |||||
| タイトル | ||||||
| タイトル | Molecular Technology | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
長田, 健介
× 長田, 健介× 長田 健介 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Electrostatic-mediated self-assembly formed from pDNA and block catiomers composed of a neutral block and a cationic block has been attracting attention as a potential systemic gene delivery system. The mission of thus formed polyplex micelles is to deliver plasmid DNA (pDNA) encoding therapeutic gene into nucleus of targeted cells and to exert transgene expression. Key issues are controlled packaging of plasmid DNA (pDNA) into polyplex micelles to suitably regulate their property and rational integration of necessary functionalities to accommodate series of inherent physiological barriers in delivery. This review first focuses to unveil molecular mechanism of pDNA packaging, followed by exploration of suitable structures and required functionalities to overcome each of delivery process. Finally, molecular designs to manage entire systemic delivery process are outlined. | |||||
| 書誌情報 |
Molecular Technology 発行日 2018-10 |
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| 出版者 | ||||||
| 出版者 | WilleVCH | |||||
| ISBN | ||||||
| 識別子タイプ | ISBN | |||||
| 関連識別子 | 978-3-527-34162-7 | |||||
