@article{oai:repo.qst.go.jp:00058918,
 author = {長田, 健介 and 長田 健介},
 journal = {Molecular Technology},
 month = {Oct},
 note = {Electrostatic-mediated self-assembly formed from pDNA and block catiomers composed of a neutral block and a cationic block has been attracting attention as a potential systemic gene delivery system. The mission of thus formed polyplex micelles is to deliver plasmid DNA (pDNA) encoding therapeutic gene into nucleus of targeted cells and to exert transgene expression. Key issues are controlled packaging of plasmid DNA (pDNA) into polyplex micelles to suitably regulate their property and rational integration of necessary functionalities to accommodate series of inherent physiological barriers in delivery. This review first focuses to unveil molecular mechanism of pDNA packaging, followed by exploration of suitable structures and required functionalities to overcome each of delivery process. Finally, molecular designs to manage entire systemic delivery process are outlined.},
 title = {Molecular Technology},
 year = {2018}
}