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分子イメージングを駆使したADC の開発
https://repo.qst.go.jp/records/58796
https://repo.qst.go.jp/records/587968cdaf832-2730-4151-b88c-b3f3d0a9fc0f
| Item type | 一般雑誌記事 / Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-11-30 | |||||
| タイトル | ||||||
| タイトル | 分子イメージングを駆使したADC の開発 | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
安永正浩
× 安永正浩× 眞鍋史乃× 辻, 厚至× 古田大× 緒方是嗣× 古賀宣勝× 藤原悠起× 佐賀恒夫× 松村保広× 辻 厚至 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Antibodydrug conjugates (ADCs) comprise an antibody, a linker, and a drug or payload. The selection of a tumor-speciˆc antibody and development of a linker having an e‹cient controlled drug release (CDR) are critical steps in developing a fully functional and eŠective ADC. In our research strategy, molecular imaging technologies have been employed to evaluate the e‹ciency of antibody delivery and CDR of the linker. In preclinical setting, antibody delivery into the tumor area or antibody penetration through the tumor stroma in malignant lymphoma or pancreatic tumor was evaluated by in vivo ‰uorescence imaging technique. Positron emission tomography (PET) imaging studies were conducted using 89Zr-labeled antibody to evaluate tumor targeting in a spontaneous carcinogenesis model. The model had dense stroma and was pathophysiologically very similar to human cancer. The drug imaging system, using microscopic mass spectroscopy (MMS) with enhanced resolution and sensitivity, was used for the evaluation of CDR. Paclitaxel (PTX)-incorporated micelle, a high-molecular-weight (HMW) carrier with CDR, showing similar properties as those of ADC, was analyzed. In contrast to free PTX, micelle selectively increased drug accumulation into the tumor and reduced toxicity in normal tissues by the enhanced permeability and retention (EPR) eŠect. Our drug imaging system has been used recently to evaluate the CDR of the ADC-linker.We present our work on the development of ADC using amolecular imaging technique. |
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| 書誌情報 |
YAKUGAKU ZASSHI 巻 137, 号 5, p. 535-544, 発行日 2017-05 |
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| 出版者 | ||||||
| 出版者 | 公益社団法人 日本薬学会 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0031-6903 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.jstage.jst.go.jp/article/yakushi/137/5/137_16-00255-3/_article/-char/ja | |||||
| 関連名称 | https://www.jstage.jst.go.jp/article/yakushi/137/5/137_16-00255-3/_article/-char/ja | |||||
