{"created":"2023-05-15T14:42:54.733019+00:00","id":58796,"links":{},"metadata":{"_buckets":{"deposit":"0cf6ab50-0daf-40aa-a4cd-2b6fefcce648"},"_deposit":{"created_by":1,"id":"58796","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"58796"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00058796","sets":["11"]},"author_link":["586406","586404","586401","586397","586398","586402","586405","586399","586403","586400"],"item_10004_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-05","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"544","bibliographicPageStart":"535","bibliographicVolumeNumber":"137","bibliographic_titles":[{"bibliographic_title":"YAKUGAKU ZASSHI"}]}]},"item_10004_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Antibodydrug conjugates (ADCs) comprise an antibody, a linker, and a drug or payload. The selection of a\ntumor-speciˆc antibody and development of a linker having an e‹cient controlled drug release (CDR) are critical steps\nin developing a fully functional and eŠective ADC. In our research strategy, molecular imaging technologies have been\nemployed to evaluate the e‹ciency of antibody delivery and CDR of the linker. In preclinical setting, antibody delivery\ninto the tumor area or antibody penetration through the tumor stroma in malignant lymphoma or pancreatic tumor was\nevaluated by in vivo ‰uorescence imaging technique. Positron emission tomography (PET) imaging studies were conducted\nusing 89Zr-labeled antibody to evaluate tumor targeting in a spontaneous carcinogenesis model. The model had\ndense stroma and was pathophysiologically very similar to human cancer. The drug imaging system, using microscopic\nmass spectroscopy (MMS) with enhanced resolution and sensitivity, was used for the evaluation of CDR. Paclitaxel\n(PTX)-incorporated micelle, a high-molecular-weight (HMW) carrier with CDR, showing similar properties as those\nof ADC, was analyzed. In contrast to free PTX, micelle selectively increased drug accumulation into the tumor and\nreduced toxicity in normal tissues by the enhanced permeability and retention (EPR) eŠect. Our drug imaging system\nhas been used recently to evaluate the CDR of the ADC-linker.We present our work on the development of ADC using amolecular imaging technique.","subitem_description_type":"Abstract"}]},"item_10004_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"公益社団法人 日本薬学会"}]},"item_10004_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://www.jstage.jst.go.jp/article/yakushi/137/5/137_16-00255-3/_article/-char/ja"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.jstage.jst.go.jp/article/yakushi/137/5/137_16-00255-3/_article/-char/ja","subitem_relation_type_select":"URI"}}]},"item_10004_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0031-6903","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"安永正浩"}],"nameIdentifiers":[{"nameIdentifier":"586397","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"眞鍋史乃"}],"nameIdentifiers":[{"nameIdentifier":"586398","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"辻, 厚至"}],"nameIdentifiers":[{"nameIdentifier":"586399","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"古田大"}],"nameIdentifiers":[{"nameIdentifier":"586400","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"緒方是嗣"}],"nameIdentifiers":[{"nameIdentifier":"586401","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"古賀宣勝"}],"nameIdentifiers":[{"nameIdentifier":"586402","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤原悠起"}],"nameIdentifiers":[{"nameIdentifier":"586403","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐賀恒夫"}],"nameIdentifiers":[{"nameIdentifier":"586404","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"松村保広"}],"nameIdentifiers":[{"nameIdentifier":"586405","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"辻 厚至","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"586406","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"分子イメージングを駆使したADC の開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"分子イメージングを駆使したADC の開発"}]},"item_type_id":"10004","owner":"1","path":["11"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-11-30"},"publish_date":"2017-11-30","publish_status":"0","recid":"58796","relation_version_is_last":true,"title":["分子イメージングを駆使したADC の開発"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T22:12:05.072599+00:00"}