WEKO3
アイテム
アルツハイマー病における神経炎症の生体イメージング
https://repo.qst.go.jp/records/58450
https://repo.qst.go.jp/records/58450792f7088-a871-40e1-8526-804822129246
| Item type | 一般雑誌記事 / Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2014-05-26 | |||||
| タイトル | ||||||
| タイトル | アルツハイマー病における神経炎症の生体イメージング | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
樋口, 真人
× 樋口, 真人× 季, 斌× 前田, 純× Anna, Barron× 須原, 哲也× Higuchi, Makoto× Ji, Bin× Maeda, Jun× Barron, Anna× Suhara, Tetsuya |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Immunocompetent cells in the brain as exemplified by microglia are crucially involved in the homeostasis of local environment by protecting of neurons against toxic stimuli, while they also exert neurotoxicity in pathological conditions. Translocator protein (TSPO) is a mitochondrial component functioning in the neurosteroidogenesis, and has attracted research interests as its upregulation in deleterious microglia can be visualized in living brains with positron emission tomography (PET) and specific radioligands. Although TSPO ligands currently available for PET imaging are of limited utility in diagnostic and therapeutic assessments of Alzheimer’s disease (AD) patients, preclinical PET assays of animals modeling AD can facilitate development of new imaging agents with high sensitivity and selectivity for microglial TSPO. In vivo imaging of other inflammatory elements such as cyclooxygenases would also help to monitor multifunctionality of microglia and associated cells in combination with TSPO-PET. | |||||
| 書誌情報 |
Dementia Japan 巻 28, 号 2, p. 211-219, 発行日 2014-05 |
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