@article{oai:repo.qst.go.jp:00058450,
 author = {樋口, 真人 and 季, 斌 and 前田, 純 and Anna, Barron and 須原, 哲也 and Higuchi, Makoto and Ji, Bin and Maeda, Jun and Barron, Anna and Suhara, Tetsuya},
 issue = {2},
 journal = {Dementia Japan},
 month = {May},
 note = {Immunocompetent cells in the brain as exemplified by microglia are crucially involved in the homeostasis of local environment by protecting of neurons against toxic stimuli, while they also exert neurotoxicity in pathological conditions. Translocator protein (TSPO) is a mitochondrial component functioning in the neurosteroidogenesis, and has attracted research interests as its upregulation in deleterious microglia can be visualized in living brains with positron emission tomography (PET) and specific radioligands. Although TSPO ligands currently available for PET imaging are of limited utility in diagnostic and therapeutic assessments of Alzheimer’s disease (AD) patients, preclinical PET assays of animals modeling AD can facilitate development of new imaging agents with high sensitivity and selectivity for microglial TSPO. In vivo imaging of other inflammatory elements such as cyclooxygenases would also help to monitor multifunctionality of microglia and associated cells in combination with TSPO-PET.},
 pages = {211--219},
 title = {アルツハイマー病における神経炎症の生体イメージング},
 volume = {28},
 year = {2014}
}