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X-ray-induced radioresistance against high-LET radiations from accelerated neon-ion beams in mice.
https://repo.qst.go.jp/records/58048
https://repo.qst.go.jp/records/5804818deb875-1385-4a99-a5ed-623705bb824a
| Item type | 一般雑誌記事 / Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2012-03-22 | |||||
| タイトル | ||||||
| タイトル | X-ray-induced radioresistance against high-LET radiations from accelerated neon-ion beams in mice. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Bing, Wang
× Bing, Wang× Tanaka, Kaoru× Ninomiya, Yasuharu× Maruyama, Kouichi× Vares, Guillaume× Eguchi-Kasai, Kiyomi× Nenoi, Mitsuru× 王 冰× 田中 薫× 二宮 康晴× 丸山 耕一× Ｇｕｉｌｌａｕｍｅ Ｖａｒｅｓ× 笠井 清美× 根井 充 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Low LET radiation-induced adaptive response (AR) against the detrimental effects from high LET radiation has not been well studied in vivo. Using 30-day survival in mice after challenging irradiations as the index, we previously demonstrated that a priming dose of 0.5 Gy X-rays could significantly reduce the mortality from the high challenging irradiations with accelerated carbon or silicon particles, but not iron particles. In the present work, induction of AR by the priming dose of 0.5 Gy X-rays in combination with a challenging dose of 5.5 Gy with accelerated neon ions was further investigated in the same system with the same endpoint. Results showed that the priming dose of 0.5 Gy X-rays could markedly reduce the mortality from the challenging dose of 5.5 Gy neon ions. Taking together, the priming dose of 0.5 Gy X-rays could induce AR against the lethality caused by the challenging irradiations from carbon, neon and silicon, but iron particles, of which the LET values of about 15, 30 and 55, and 200 keV/micrometer, respectively. It is suggested that AR could be induced by priming low LET X-rays in combination with subsequent challenging high LET irradiations from certain kinds of accelerated heavy ions. The successful induction of AR would be possible an event relating to the LET value or/and the heavy ion particle of the challenging irradiations. These findings would provide a new insight into the study on radiation-induced AR in vivo. | |||||
| 書誌情報 |
Current Topics in Ionizing Radiation Research p. 199-214, 発行日 2012-03 |
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| 出版者 | ||||||
| 出版者 | InTech - Open Access Company | |||||
| ISBN | ||||||
| 識別子タイプ | ISBN | |||||
| 関連識別子 | 978-9-5351-0196 | |||||
