@article{oai:repo.qst.go.jp:00058048,
 author = {Bing, Wang and Tanaka, Kaoru and Ninomiya, Yasuharu and Maruyama, Kouichi and Vares, Guillaume and Eguchi-Kasai, Kiyomi and Nenoi, Mitsuru and 王 冰 and 田中 薫 and 二宮 康晴 and 丸山 耕一 and Ｇｕｉｌｌａｕｍｅ Ｖａｒｅｓ and 笠井 清美 and 根井 充},
 journal = {Current Topics in Ionizing Radiation Research},
 month = {Mar},
 note = {Low LET radiation-induced adaptive response (AR) against the detrimental effects from high LET radiation has not been well studied in vivo. Using 30-day survival in mice after challenging irradiations as the index, we previously demonstrated that a priming dose of 0.5 Gy X-rays could significantly reduce the mortality from the high challenging irradiations with accelerated carbon or silicon particles, but not iron particles. In the present work, induction of AR by the priming dose of 0.5 Gy X-rays in combination with a challenging dose of 5.5 Gy with accelerated neon ions was further investigated in the same system with the same endpoint. Results showed that the priming dose of 0.5 Gy X-rays could markedly reduce the mortality from the challenging dose of 5.5 Gy neon ions. Taking together, the priming dose of 0.5 Gy X-rays could induce AR against the lethality caused by the challenging irradiations from carbon, neon and silicon, but iron particles, of which the LET values of about 15, 30 and 55, and 200 keV/micrometer, respectively. It is suggested that AR could be induced by priming low LET X-rays in combination with subsequent challenging high LET irradiations from certain kinds of accelerated heavy ions. The successful induction of AR would be possible an event relating to the LET value or/and the heavy ion particle of the challenging irradiations. These findings would provide a new insight into the study on radiation-induced AR in vivo.},
 pages = {199--214},
 title = {X-ray-induced radioresistance against high-LET radiations from accelerated neon-ion beams in mice.},
 year = {2012}
}