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消化器癌幹細胞に対する重粒子線照射による細胞生存とDNA修復への影響(12J371a)
https://repo.qst.go.jp/records/56148
https://repo.qst.go.jp/records/56148dd5a4897-9b2d-4e66-a909-6be461f46b5d
| Item type | 一般雑誌記事 / Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2019-02-12 | |||||
| タイトル | ||||||
| タイトル | 消化器癌幹細胞に対する重粒子線照射による細胞生存とDNA修復への影響(12J371a) | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
崔, 星
× 崔, 星× 白井, 敏之× 崔 星× 白井 敏之 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | To investigate whether carbon ion beam had beneficial effects by targeting putative human cholangiocarcinoma stem cells, cancer stem-like cells sorted from HuCCT1 were treated with or without carbon ion or X-ray irradiation and then colony and spheroid formation assays, H2AX foci immunofluorescence assays, as well as xenograft tumor growth control analyses were performed. CD44+/ESA+ cells significantly have higher number of colonies, spheres compared to CD44-/ESA- cells. CD44+/ESA+ cells were showed radioresistance to both X-ray and carbon ion beam, but the carbon ion beam more effectively killed those of cancer stem-like cells. In addition, carbon ion beam has more potential to eradicate xenograft tumors compared to X-rays at isoeffective doses. In conclusion, carbon ion beam has a great advantage in targeting radioresistant human cholangiocarcinoma cells in vitro and in vivo. | |||||
| 書誌情報 |
平成25年度放射線医学総合研究所重粒子線がん治療装置等共同利用研究報告書, 発行日 2014-02 |
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