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消化器癌幹細胞に対する重粒子線照射による細胞生存とDNA修復への影響（J101a）
https://repo.qst.go.jp/records/56145
https://repo.qst.go.jp/records/56145b6f6d258-a1b2-4c58-9c18-1469e378c5e4
| Item type | 一般雑誌記事 / Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2019-02-12 | |||||
| タイトル | ||||||
| タイトル | 消化器癌幹細胞に対する重粒子線照射による細胞生存とDNA修復への影響（J101a） | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
崔, 星
× 崔, 星× Ｇｕｉｌｌａｕｍｅ, Ｖａｒｅｓ× 鈴木, 雅雄× 崔 星× Ｇｕｉｌｌａｕｍｅ Ｖａｒｅｓ× 鈴木 雅雄 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | In this study, we try to investigate whether carbon ion beam alone or in combination with gemcitabine (GEM) and cisplatin (CDDP) is effective in targeting putative human cholangicarcinoma stem cells in vitro and in vivo. Colony and spheroid formation assay as well as in vivo tumorigenic assay showed that CD44+/ESA+ cells exactly have cancer stem cells (CSCs) properties compared to CD44-/ESA- cells. The number of colony and spheroid formed from CSCs was remarkably reduced after carbon ion beam combined with GEM and CDDP compared to that of X-ray or carbon ion beam alone. A more large number and large-sized gamma-H2AX foci were observed in CSCs after 24 h carbon ion beam combined with GEM and CDDP compared to that of X-ray or carbon ion beam alone. High dose of carbon ion beam with 35 Gy alone or with 25 Gy of relative low carbon ion beam combined with GEM and CDDP induced more severe xenograft tumor cell cavitation and fibrosis and significantly regressed the tumors compared to that of X-ray irradiation. Taken together, carbon ion beam alone or combined with GEM and CDDP effectively induced prolonged and more complex DNA damage, as a result effectively destroyed cholangicarcinoma stem cells in vitro and in vivo. | |||||
| 書誌情報 |
平成27年度放射線医学総合研究所重粒子線がん治療装置等共同利用研究報告書 発行日 2016-02 |
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