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粒子治療適応拡大に向けた薬物併用療法の基礎的研究 (J103)
https://repo.qst.go.jp/records/56144
https://repo.qst.go.jp/records/561447636484a-aa31-4ee5-8347-908d38d5de6c
| Item type | 一般雑誌記事 / Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2019-02-12 | |||||
| タイトル | ||||||
| タイトル | 粒子治療適応拡大に向けた薬物併用療法の基礎的研究 (J103) | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
崔, 星
× 崔, 星× 鈴木, 雅雄× 崔 星× 鈴木 雅雄 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Malignant mesothelioma (MM) is extremely aggressive and a typical refractory cancer. In this study we investigated how effective on killing MM cells by carbon ion beam alone or in combination with cisplatin (CDDP) in vitro. Carbon ion beam dose-independently suppressed MESO1 viability and in combination with CDDP (25M) significantly enhanced its action. Spheroid formation ability of cancer stem like CD24+/CD26+ cells was significantly inhibited by carbon ion beam combined with CDDP. Apoptosis analysis showed that the percentage of apoptotic cells was dose-dependently increased after carbon ion beam and it was further increased when combined with CDDP. Quantitative real time PCR analysis showed that expression of apoptosis-related BAX and autophagy-related Beclin1 and LC3 was significantly enhanced by carbon ion beam in combination with CDDP compared to carbon ion beam alone. In conclusion, carbon ion beam combined with CDDP has superior potential to kill MM cells including CSCs with enhanced apoptosis. | |||||
| 書誌情報 |
平成28年度放射線医学総合研究所重粒子線がん治療装置等共同利用研究報告書 発行日 2017-02 |
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