{"created":"2023-05-15T14:40:56.378409+00:00","id":56144,"links":{},"metadata":{"_buckets":{"deposit":"62de0d80-f03a-461d-98b5-d7d5492b5d39"},"_deposit":{"created_by":1,"id":"56144","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"56144"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00056144","sets":["7"]},"author_link":["574342","574340","574341","574339"],"item_10004_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-02","bibliographicIssueDateType":"Issued"},"bibliographic_titles":[{"bibliographic_title":"平成28年度放射線医学総合研究所重粒子線がん治療装置等共同利用研究報告書"}]}]},"item_10004_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Malignant mesothelioma (MM) is extremely aggressive and a typical refractory cancer. In this study we investigated how effective on killing MM cells by carbon ion beam alone or in combination with cisplatin (CDDP) in vitro. Carbon ion beam dose-independently suppressed MESO1 viability and in combination with CDDP (25M) significantly enhanced its action. Spheroid formation ability of cancer stem like CD24+/CD26+ cells was significantly inhibited by carbon ion beam combined with CDDP. Apoptosis analysis showed that the percentage of apoptotic cells was dose-dependently increased after carbon ion beam and it was further increased when combined with CDDP. Quantitative real time PCR analysis showed that expression of apoptosis-related BAX and autophagy-related Beclin1 and LC3 was significantly enhanced by carbon ion beam in combination with CDDP compared to carbon ion beam alone. In conclusion, carbon ion beam combined with CDDP has superior potential to kill MM cells including CSCs with enhanced apoptosis.","subitem_description_type":"Abstract"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"崔, 星"}],"nameIdentifiers":[{"nameIdentifier":"574339","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鈴木, 雅雄"}],"nameIdentifiers":[{"nameIdentifier":"574340","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"崔 星","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"574341","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鈴木 雅雄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"574342","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"粒子治療適応拡大に向けた薬物併用療法の基礎的研究 (J103)","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"粒子治療適応拡大に向けた薬物併用療法の基礎的研究 (J103)"}]},"item_type_id":"10004","owner":"1","path":["7"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-02-12"},"publish_date":"2019-02-12","publish_status":"0","recid":"56144","relation_version_is_last":true,"title":["粒子治療適応拡大に向けた薬物併用療法の基礎的研究 (J103)"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T22:41:27.427249+00:00"}