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消化器癌幹細胞に対する重粒子線照射による細胞生存とDNA修復への影響（J101）
https://repo.qst.go.jp/records/56143
https://repo.qst.go.jp/records/56143fb267a1d-1fde-41e0-a0b4-2b2ec564bc5e
| Item type | 一般雑誌記事 / Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2019-02-12 | |||||
| タイトル | ||||||
| タイトル | 消化器癌幹細胞に対する重粒子線照射による細胞生存とDNA修復への影響（J101） | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
崔, 星
× 崔, 星× 鈴木, 雅雄× 崔 星× 鈴木 雅雄 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | In this study, we try to investigate whether carbon ion beam alone or in combination with sorafenib is effective in targeting putative human liver cancer cells in vitro and in vivo. Colony and spheroid formation assay as well as in vivo tumorigenic assay showed that CD133+/CD90+ or CD44+/ESA+ cells exactly have cancer stem cells (CSCs) properties compared to CD133-/CD90- or CD44-/ESA- cells. The number of colony and spheroid formed from CSCs was remarkably reduced after carbon ion beam combined with sorafenib compared to that of X-ray or carbon ion beam alone. Carbon ion beam combined with sorafenib significantly increased apoptosis-related gene Bax expression, but reduced autophagy-related gene p62 expression compared to that of X-ray or carbon ion beam alone. High dose of carbon ion beam with 35 Gy alone or with 25 Gy of relative low carbon ion beam combined with sorafenib induced more severe xenograft tumor cell cavitation and fibrosis and significantly regressed the tumors compared to that of X-ray irradiation. Taken together, carbon ion beam combined with sorafenib effectively suppressed CSC spheroid formation and induced alteration of multiple gene expression, and destroyed liver cancer cells including CSCs in vitro and in vivo. | |||||
| 書誌情報 |
平成28年度放射線医学総合研究所重粒子線がん治療装置等共同利用研究報告書 発行日 2017-02 |
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