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Role of stem cells in radioresponse of tumor cells toward high-LET particles and the involvement of endogenous H2S pathway
https://repo.qst.go.jp/records/56066
https://repo.qst.go.jp/records/56066f5ad5b4a-311b-46af-be28-304da9be74dc
| Item type | 一般雑誌記事 / Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-11-09 | |||||
| タイトル | ||||||
| タイトル | Role of stem cells in radioresponse of tumor cells toward high-LET particles and the involvement of endogenous H2S pathway | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Pang, Yan
× Pang, Yan× Zhang, Hang× Fu, Jiamei× Konishi, Teruaki× Kobayashi, Alisa× Furusawa, Yoshiya× Uchihori, Yukio× Shao, Chunlin× 小西 輝昭× 小林 亜利紗× 古澤 佳也× 内堀 幸夫 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Growing evidence suggests that low-LET radiation can paradoxically promote tumor invasion and metastatic processes, however, there are limited reports concerning the effect of high-LET radiation on the invasiveness and migration of tumor cells, and the molecular mechanism remain largely unknown. Here, we found that carbon ions and gamma radiation can both induce a converse effect on cellular migration and invasion in HCT116 and DLD-1 cells, and this may be related to the opposite EMT process in these two cell lines, which are regulated by different phosphorylation of GSK3β protein after radiation. | |||||
| 書誌情報 |
平成28 年度 放射線医学総合研究所 重粒子線がん治療装置等 共同利用研究報告書 巻 2016, 号 HIMAC-145, p. 26-27, 発行日 2017-11 |
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| 出版者 | ||||||
| 出版者 | 放射線医学総合研究所 | |||||
