@article{oai:repo.qst.go.jp:00056066, author = {Pang, Yan and Zhang, Hang and Fu, Jiamei and Konishi, Teruaki and Kobayashi, Alisa and Furusawa, Yoshiya and Uchihori, Yukio and Shao, Chunlin and 小西 輝昭 and 小林 亜利紗 and 古澤 佳也 and 内堀 幸夫}, issue = {HIMAC-145}, journal = {平成28 年度 放射線医学総合研究所 重粒子線がん治療装置等 共同利用研究報告書}, month = {Nov}, note = {Growing evidence suggests that low-LET radiation can paradoxically promote tumor invasion and metastatic processes, however, there are limited reports concerning the effect of high-LET radiation on the invasiveness and migration of tumor cells, and the molecular mechanism remain largely unknown. Here, we found that carbon ions and gamma radiation can both induce a converse effect on cellular migration and invasion in HCT116 and DLD-1 cells, and this may be related to the opposite EMT process in these two cell lines, which are regulated by different phosphorylation of GSK3β protein after radiation.}, pages = {26--27}, title = {Role of stem cells in radioresponse of tumor cells toward high-LET particles and the involvement of endogenous H2S pathway}, volume = {2016}, year = {2017} }