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Structure and repair of clustered DNA damage after heavy ion exposure (15J415)
https://repo.qst.go.jp/records/55994
https://repo.qst.go.jp/records/55994ad679dba-6654-432f-adae-ba6b4757ae87
| Item type | 一般雑誌記事 / Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-01-27 | |||||
| タイトル | ||||||
| タイトル | Structure and repair of clustered DNA damage after heavy ion exposure (15J415) | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Staaf, Elina
× Staaf, Elina× Kobayashi, Alisa× Abbrizal, Farizal Tengku Ahmad Tengku× Furusawa, Yoshiya× Kodaira, Satoshi× Stenerlöw, Bo× Konishi, Teruaki× 小林 亜利紗× 古澤 佳也× 小平 聡× 小西 輝昭 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Clustered DNA damage is challenging for cells to repair, due to multiple lesions and lesion types being present within a relatively small volume of DNA. Furthermore, cells that are already undergoing repair after particle exposure may be less responsive in repairing the damage from a second particle later. Time progression has been studied with traditional immunofluorescence, but so far not many studies have managed to penetrate to nanoscale resolution, which is possible with electron microscopy. We are using Carbon and Iron ions near the RBE-LET peak to generate dense tracks. We will study the outcomes by high-resolution immunoelectron microscopy of individual particle tracks, and will supplement following DNA repair protein time courses and assessing resulting chromosomal damage. | |||||
| 書誌情報 |
平成27 年度放射線医学総合研究所 重粒子線がん治療装置等 共同利用研究報告書 巻 HIMAC-144, p. 138-139, 発行日 2016-09 |
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| 出版者 | ||||||
| 出版者 | 放射線医学総合研究所 | |||||
