@article{oai:repo.qst.go.jp:00055994, author = {Staaf, Elina and Kobayashi, Alisa and Abbrizal, Farizal Tengku Ahmad Tengku and Furusawa, Yoshiya and Kodaira, Satoshi and Stenerlöw, Bo and Konishi, Teruaki and 小林 亜利紗 and 古澤 佳也 and 小平 聡 and 小西 輝昭}, journal = {平成27 年度放射線医学総合研究所 重粒子線がん治療装置等 共同利用研究報告書}, month = {Sep}, note = {Clustered DNA damage is challenging for cells to repair, due to multiple lesions and lesion types being present within a relatively small volume of DNA. Furthermore, cells that are already undergoing repair after particle exposure may be less responsive in repairing the damage from a second particle later. Time progression has been studied with traditional immunofluorescence, but so far not many studies have managed to penetrate to nanoscale resolution, which is possible with electron microscopy. We are using Carbon and Iron ions near the RBE-LET peak to generate dense tracks. We will study the outcomes by high-resolution immunoelectron microscopy of individual particle tracks, and will supplement following DNA repair protein time courses and assessing resulting chromosomal damage.}, pages = {138--139}, title = {Structure and repair of clustered DNA damage after heavy ion exposure (15J415)}, volume = {HIMAC-144}, year = {2016} }