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Cell death bypass mechanisms in DNA damage response of mammalian cells after exposure with heavy ions relevant for Space radiation environment
https://repo.qst.go.jp/records/55931
https://repo.qst.go.jp/records/55931f1d5f90b-7d9f-4355-90a0-85d03ca41cd0
| Item type | 一般雑誌記事 / Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2015-02-09 | |||||
| タイトル | ||||||
| タイトル | Cell death bypass mechanisms in DNA damage response of mammalian cells after exposure with heavy ions relevant for Space radiation environment | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Baumstark-Khan, Christa
× Baumstark-Khan, Christa× F, Spitta Luis× E, Hellweg Christine× Henschenmacher, Sebastian× Bernd, Diegeler Sebastian× Konishi, Teruaki× Uchihori, Yukio× 小西 輝昭× 内堀 幸夫 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | For sake of better risk assessment for the astronaut, the cellular response to such ionizing radiation qualities, as predominate in Space, needs to be better understood. Cell cycle control as a central element in DNA damange response will be investigated as it is a central switch for cellular decision making between life and death. Thus cell death bypass mechnisms in DNA damage response of mammalian cells will be investigated after heavy ion exposure relevant for the Space radiation environment. The RBE-LET dependency will be determined for different biological endpoints. Of special interest are the activation of transcription factors and the identification of genes expressed in DNA damange response after high LET exposure. | |||||
| 書誌情報 |
2013 Annual Report of the Research Project with Heavy Ions at NIRS-HIMAC 巻 NIRS-M-273, 号 HIMAC-141, p. 110-111, 発行日 2014-10 |
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