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重粒子線による発がんの被ばく時年齢依存性
https://repo.qst.go.jp/records/55882
https://repo.qst.go.jp/records/55882a90f90fe-0173-4bfd-8ba0-3d7febfe283c
| Item type | 一般雑誌記事 / Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-11-14 | |||||
| タイトル | ||||||
| タイトル | 重粒子線による発がんの被ばく時年齢依存性 | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
柿沼, 志津子
× 柿沼, 志津子× 今岡, 達彦× 高畠, 貴志× 西村, まゆみ× 臺野, 和広× 尚, 奕× 澤井, 知子× 森岡, 孝満× 岩田, 健一× 甘崎, 佳子× 平野, しのぶ× 久保山, 歩美× 砂押, 正章× 島田, 義也× 柿沼 志津子× 今岡 達彦× 高畠 貴志× 西村 まゆみ× 臺野 和広× 尚 奕× 澤井 知子× 森岡 孝満× 岩田 健一× 甘崎 佳子× 坂入 しのぶ× 久保山 歩美× 砂押 正章× 島田 義也 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | We carried out Biological effects of heavy ions have been extensively investigated using HIMAC synchrotron. One of major concerns about heavy particles is its carcinogenic potential. However, the data are still scanty. We previously showed that carbon-ion irradiation resulted in life span shortening and tumor induction in B6C3F1 mice1-3. It is known that a genetic background and an age at exposure are important factors. In the present study, we first focused on the influence of genetic background on the relative biological effectiveness (RBE) for cancer induction. Two mouse strains, C57BL/6 and C3H, were exposed weekly to whole-body carbon-ion or X-ray irradiation at 0.3-2.0 Gy for 4 consecutive weeks. Then, we investigated life span and tumor induction in these mice. C57BL/6 mice were highly susceptible to radiation-induced thymic lymphomas at the higher dose (1.2-1.6 Gy x 4), while C3H mice were resistant. The RBE of carbon-ions at the 50% incidence of thymic lymphomas in C57BL/6 mice was 1.1. RBE in C3H mice is under investigation. We also attempted to determine the influence of age at exposure for tumor induction. Male and female B6C3F1 mice at several age points were exposed to whole-body carbon-ion or g-ray irradiation at 0.2 and 2.0 Gy, and were observed under SFP condition. | |||||
| 書誌情報 |
放射線医学総合研究所重粒子線がん治療装置等共同利用研究報告書 p. 000, 発行日 2011-04 |
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| 出版者 | ||||||
| 出版者 | 放医研 | |||||
