@article{oai:repo.qst.go.jp:00055882,
 author = {柿沼, 志津子 and 今岡, 達彦 and 高畠, 貴志 and 西村, まゆみ and 臺野, 和広 and 尚, 奕 and 澤井, 知子 and 森岡, 孝満 and 岩田, 健一 and 甘崎, 佳子 and 平野, しのぶ and 久保山, 歩美 and 砂押, 正章 and 島田, 義也 and 柿沼 志津子 and 今岡 達彦 and 高畠 貴志 and 西村 まゆみ and 臺野 和広 and 尚 奕 and 澤井 知子 and 森岡 孝満 and 岩田 健一 and 甘崎 佳子 and 坂入 しのぶ and 久保山 歩美 and 砂押 正章 and 島田 義也},
 journal = {放射線医学総合研究所重粒子線がん治療装置等共同利用研究報告書},
 month = {Apr},
 note = {We carried out Biological effects of heavy ions have been extensively investigated using HIMAC synchrotron. One of major concerns about heavy particles is its carcinogenic potential. However, the data are still scanty. We previously showed that carbon-ion irradiation resulted in life span shortening and tumor induction in B6C3F1 mice1-3. It is known that a genetic background and an age at exposure are important factors. In the present study, we first focused on the influence of genetic background on the relative biological effectiveness (RBE) for cancer induction. Two mouse strains, C57BL/6 and C3H, were exposed weekly to whole-body carbon-ion or X-ray irradiation at 0.3-2.0 Gy for 4 consecutive weeks. Then, we investigated life span and tumor induction in these mice. C57BL/6 mice were highly susceptible to radiation-induced thymic lymphomas at the higher dose (1.2-1.6 Gy x 4), while C3H mice were resistant. The RBE of carbon-ions at the 50% incidence of thymic lymphomas in C57BL/6 mice was 1.1. RBE in C3H mice is under investigation. We also attempted to determine the influence of age at exposure for tumor induction. Male and female B6C3F1 mice at several age points were exposed to whole-body carbon-ion or g-ray irradiation at 0.2 and 2.0 Gy, and were observed under SFP condition.},
 title = {重粒子線による発がんの被ばく時年齢依存性},
 year = {2011}
}