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Braggピーク近傍の重粒子イオン照射による細胞致死及びDNA二本鎖切断誘発率の測定
https://repo.qst.go.jp/records/55615
https://repo.qst.go.jp/records/556158ed30cd5-1e8d-489a-a1ad-d6f8aeab469f
| Item type | 一般雑誌記事 / Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2008-09-03 | |||||
| タイトル | ||||||
| タイトル | Braggピーク近傍の重粒子イオン照射による細胞致死及びDNA二本鎖切断誘発率の測定 | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
小西, 輝昭
× 小西, 輝昭× 安田, 仲宏× 北村, 尚× 前田, 武× 児玉, 久美子× 今関, 等× 古澤, 佳也× 檜枝, 光太郎× 小西 輝昭× 安田 仲宏× 北村 尚× 前田 武× 児玉 久美子× 今関 等× 古澤 佳也× 檜枝 光太郎 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | CHO-K1 cells were irradiated with protons and Ne ions near the Bragg peak at the Medium Energy Beam (MEXP) Course. Neon ions were transported to MEXP course at 6 MeV/n and led into air, and then irradiated to the cells. Ion energy (or the LETs) was selected by changing the distance between the beam exit and the sample position. For protons, we decreased the ion energy to 4.3 MeV from 6MeV by controlling linac accelerators. For measurement of cell inactivation, 4.3 MeV protons were decreased its energy by air as an absorber to 3.4, 2.6, and 2.0. The effect for cell inactivation higher with low energy protons. For Ne ion, we measured the cell inactivation cross-section by obtaining the survival curves at two different positions of Bragg curves, which showed lower inactivation cross section at higher LET. This may be due to drastic thin down of ion track radius at near the Bragg peak. | |||||
| 書誌情報 |
放射線医学総合研究所重粒子線がん治療装置等共同利用研究報告書 巻 NIRS-M-214, 号 HIMAC-129, p. 92-93, 発行日 2008-06 |
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| 出版者 | ||||||
| 出版者 | 放医研 | |||||
