WEKO3
アイテム
休止期腫瘍細胞挙動から見た重イオン線照射効果解析
https://repo.qst.go.jp/records/55599
https://repo.qst.go.jp/records/55599b9876325-4c6e-4624-a6ac-708b1429660c
| Item type | 一般雑誌記事 / Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2008-01-16 | |||||
| タイトル | ||||||
| タイトル | 休止期腫瘍細胞挙動から見た重イオン線照射効果解析 | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
増永, 慎一郎
× 増永, 慎一郎× 小野, 公二× 鵜澤, 玲子× 平山, 亮一× 古澤, 佳也× 小池, 幸子× 安藤, 興一× 増永 慎一郎× 小野 公二× 鵜澤 玲子× 平山 亮一× 古澤 佳也× 小池 幸子× 安藤 興一 |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | SCC VII tumor-bearing mice received a continuous administration of 5-bromo-2'-deoxyuridine (BrdU) to label all intratumor proliferating (P) cells. Then, they received 290 MeV/u carbon ion beam and gamma-ray irradiation at a dose-rate of approximately 1.0 Gy/min and 2.5 Gy/min, respectively. Immediately or 12 hours after irradiation, the tumors were isolated and incubated with a cytokinesis blocker, and the micronucleus (MN) frequency in cells without BrdU labeling (= Q cells) was determined using immunofluorescence staining for BrdU. The MN frequency in the total (= P+Q) tumor cell populations was determined using tumors that were not pretreated with BrdU. The difference in radiosensitivity between total and Q cell populations was markedly reduced with carbon ion beams, especially with the higher value of linear energy transfer (LET), compared with low LET gamma-rays. Potentially lethal damage repair by Q cells was efficiently inhibited with carbon ion beams, especially with higher LET, compared with gamma-rays. Carbon ion beam irradiation could efficiently reduce the dependency of radiosensitivity on their heterogeneity in solid tumors. From the viewpoint of solid tumor control as a whole, including intratumor Q cell control, carbon ion beams, especially with higher LET, were very useful for suppressing the dependency on the heterogeneity in solid tumors, compared with low LET gamma-rays. | |||||
| 書誌情報 |
放射線医学総合研究所重粒子線がん治療装置等共同利用研究報告書 巻 2007, p. 77-78, 発行日 2007-06 |
|||||
| 出版者 | ||||||
| 出版者 | 放医研 | |||||
