@article{oai:repo.qst.go.jp:00055599,
 author = {増永, 慎一郎 and 小野, 公二 and 鵜澤, 玲子 and 平山, 亮一 and 古澤, 佳也 and 小池, 幸子 and 安藤, 興一 and 増永 慎一郎 and 小野 公二 and 鵜澤 玲子 and 平山 亮一 and 古澤 佳也 and 小池 幸子 and 安藤 興一},
 journal = {放射線医学総合研究所重粒子線がん治療装置等共同利用研究報告書},
 month = {Jun},
 note = {SCC VII tumor-bearing mice received a continuous administration of 5-bromo-2'-deoxyuridine (BrdU) to label all intratumor proliferating (P) cells. Then, they received 290 MeV/u carbon ion beam and gamma-ray irradiation at a dose-rate of approximately 1.0 Gy/min and 2.5 Gy/min, respectively. Immediately or 12 hours after irradiation, the tumors were isolated and incubated with a cytokinesis blocker, and the micronucleus (MN) frequency in cells without BrdU labeling (= Q cells) was determined using immunofluorescence staining for BrdU. The MN frequency in the total (= P+Q) tumor cell populations was determined using tumors that were not pretreated with BrdU. The difference in radiosensitivity between total and Q cell populations was markedly reduced with carbon ion beams, especially with the higher value of linear energy transfer (LET), compared with low LET gamma-rays. Potentially lethal damage repair by Q cells was efficiently inhibited with carbon ion beams, especially with higher LET, compared with gamma-rays. Carbon ion beam irradiation could efficiently reduce the dependency of radiosensitivity on their heterogeneity in solid tumors. From the viewpoint of solid tumor control as a whole, including intratumor Q cell control, carbon ion beams, especially with higher LET, were very useful for suppressing the dependency on the heterogeneity in solid tumors, compared with low LET gamma-rays.},
 pages = {77--78},
 title = {休止期腫瘍細胞挙動から見た重イオン線照射効果解析},
 volume = {2007},
 year = {2007}
}