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粒子線治療の腫瘍治療効果と障害に関する研究
https://repo.qst.go.jp/records/55598
https://repo.qst.go.jp/records/55598df30816d-bff5-433e-baa2-cb6a0b74a58c
| Item type | 一般雑誌記事 / Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2008-01-11 | |||||
| タイトル | ||||||
| タイトル | 粒子線治療の腫瘍治療効果と障害に関する研究 | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
鵜澤, 玲子
× 鵜澤, 玲子× 安藤, 興一× 小池, 幸子× 古澤, 佳也× 平山, 亮一× 松本, 孔貴× 渡邉, 雅彦× 鵜澤 玲子× 安藤 興一× 小池 幸子× 古澤 佳也× 平山 亮一× 松本 孔貴× 渡邉 雅彦 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Irradiating hind legs of C3H female mice with single doses of carbon ions induced tumors at 200-1000 days. The frequency of tumor induction increased with dose for carbon ions and gamma rays. A dose-response curve for 75 keV/um carbon ions was steeper than that for gamma rays, while a dose-response curve for 15 keV/um carbon ions was rather shallower than that for gamma rays. When isoeffect doses to induce 20 % tumor induction were used, resulting RBE values of carbon ions with15, 45 and 75 keV/um were 0.6, 1.0 and 1.4, respectively. Radiosensitivities of a tumor artificially composed of heterogeneous populations were studied. Tumors #6107 and #9037 are originally obtained by irradiating legs of C3H female mice with carbon ions and gamma rays, respectively. Cells from 5th generations of each tumor were mixed with ratios of 1 to 9 and 9 to1, and transplanted into hind legs. Dose-tumor growth delay time relationship of the heterogeneous tumors shifted toward that of radioresistant #9037 tumor after gamma-ray radiation. Contrarily, the dose-response relationship of heterogeneous tumors after 74 keV /um carbon ions shifted rather toward that of radiosensitive #6107 tumors. |
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| 書誌情報 |
放射線医学総合研究所重粒子線がん治療装置等共同利用研究報告書 巻 2007, p. 45-46, 発行日 2007-05 |
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| 出版者 | ||||||
| 出版者 | 放医研 | |||||
