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重粒子線によるDNA 主鎖切断誘発機構の研究
https://repo.qst.go.jp/records/55434
https://repo.qst.go.jp/records/55434a8325028-6c75-4213-86f3-38a911b4125e
| Item type | 一般雑誌記事 / Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2006-04-15 | |||||
| タイトル | ||||||
| タイトル | 重粒子線によるDNA 主鎖切断誘発機構の研究 | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
小西, 輝昭
× 小西, 輝昭× 檜枝, 光太郎× 佐藤, 幸夫× 安田, 仲宏× 古澤, 佳也× 小西 輝昭× 檜枝 光太郎× 佐藤 幸夫× 安田 仲宏× 古澤 佳也 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | High-LET heavy ions are more efficient than low-LET radiation in the induction of DNA double-strand breaks (dsb). The ratio of dsb to single-strand breaks (ssb) is higher for densely ionizing radiation than for sparsely ionizing radiation. However, even for Fe ions with LET of several thousands keV/um, dsb/ssb ratios not exceeding a few tenths have been reported. We have measured this ratio in solution DNA exposed to carbon ions at positions near the Bragg peak. Carbon Ions with 6 MeV/n from the Medium-Energy Beam Course at the NIRS were extracted into air through a thin metal foil. The particle fluence was directly measured by CR39 track detector. Closed circular pBR322 plasmid DNA was used, and dsb and ssb were quantitated by electrophoretic separation and ethidium bromide staining of the DNA. Our results indicate the dsb/ssb ratio is about 2 for carbon Ions close to the Bragg peak. | |||||
| 書誌情報 |
放射線医学総合研究所重粒子線がん治療装置等共同利用研究報告書 巻 2000, p. 108-109, 発行日 2001-04 |
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| 出版者 | ||||||
| 出版者 | 放医研 | |||||
