@article{oai:repo.qst.go.jp:00055434,
 author = {小西, 輝昭 and 檜枝, 光太郎 and 佐藤, 幸夫 and 安田, 仲宏 and 古澤, 佳也 and 小西 輝昭 and 檜枝 光太郎 and 佐藤 幸夫 and 安田 仲宏 and 古澤 佳也},
 journal = {放射線医学総合研究所重粒子線がん治療装置等共同利用研究報告書},
 month = {Apr},
 note = {High-LET heavy ions are more efficient than low-LET radiation in the induction of DNA double-strand breaks (dsb). The ratio of dsb to single-strand breaks (ssb) is higher for densely ionizing radiation than for sparsely ionizing radiation. However, even for Fe ions with LET of several thousands keV/um, dsb/ssb ratios not exceeding a few tenths have been reported. We have measured this ratio in solution DNA exposed to carbon ions at positions near the Bragg peak. Carbon Ions with 6 MeV/n from the Medium-Energy Beam Course at the NIRS were extracted into air through a thin metal foil. The particle fluence was directly measured by CR39 track detector. Closed circular pBR322 plasmid DNA was used, and dsb and ssb were quantitated by electrophoretic separation and ethidium bromide staining of the DNA. Our results indicate the dsb/ssb ratio is about 2 for carbon Ions close to the Bragg peak.},
 pages = {108--109},
 title = {重粒子線によるDNA 主鎖切断誘発機構の研究},
 volume = {2000},
 year = {2001}
}