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重粒子線が生成する細胞中のＤＮＡ損傷と染色体異常
https://repo.qst.go.jp/records/55243
https://repo.qst.go.jp/records/55243aeafbe1d-3edd-4168-afa7-3ac1aef34bfb
| Item type | 一般雑誌記事 / Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2004-01-25 | |||||
| タイトル | ||||||
| タイトル | 重粒子線が生成する細胞中のＤＮＡ損傷と染色体異常 | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
伊藤, 敦
× 伊藤, 敦× 平山, 亮一× 村山, 千恵子× 古澤, 佳也× 伊藤 敦× 平山 亮一× 村山 千恵子× 古澤 佳也 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Production of 8-hydroxy-2'-deoxyguanosine (8-OH-dG) from 2'-deoxyguanosine (dG) was examined upon irradiation with X-rays, carbon, neon or silicon ions. The LETs of heavy ions ranged from 20 to 300 keV/um. dG in aqueous solution was irradiated under air-saturated or hypoxic condition. Under the air-saturated condition, the yield of 8-OHdG decreased with increasing LET. The decreasing rate nearly paralleled with the decrease in G value of OH-radical production. On the other hand, under the hypoxic condition, the decreasing rate of 8-OH-dG yield with increasing LET was significantly lower than that obtained under the air-saturated condition. These results are consistent with the hypothesis of "oxygen-in-the-track model" previously proposed by Baverstock and others. Further research in the 8-OHdG production in cellular system is in progress. | |||||
| 書誌情報 |
放射線医学総合研究所重粒子線がん治療装置等共同利用研究報告書 巻 2002, p. 119-120, 発行日 2003-04 |
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| 出版者 | ||||||
| 出版者 | 放医研 | |||||
