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重粒子線によるがんの転移課程に及ぼす影響
https://repo.qst.go.jp/records/55236
https://repo.qst.go.jp/records/55236aa1b7e21-0aaf-41f5-b17f-5de48278818b
| Item type | 一般雑誌記事 / Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2004-01-23 | |||||
| タイトル | ||||||
| タイトル | 重粒子線によるがんの転移課程に及ぼす影響 | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
手島, 昭樹
× 手島, 昭樹× 松浦, 成昭× 池田, 聡子× 水野, 裕一× 尾方, 俊至× 野島, 久美恵× 古澤, 佳也× 手島 昭樹× 松浦 成昭× 池田 聡子× 水野 裕一× 尾方 俊至× 野島 久美恵× 古澤 佳也 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The purpose of this study is to investigate the effect of heavy ion on the processes of metastasis, especially angiogenesis. Heavy ion radiation therapy has attracted attention as an effective modality for cancer therapy because of its highly lethal effects, but the effects of heavy ion irradiation on angiogenesis have not been reported. Angiogenesis is not only a prerequisite for tumor growth and expression but also a major factor affecting the metastatic spread of malignant cells. In vivo, angiogenesis was inhibited by carbon ion irradiation in the dorsal air sac (DAS) model. In vitro, capillary-like tube structures in 3-D culture were destroyed after carbon ion irradiation concomitant with the inhibition of cell motility, migration, invasiveness, and proliferation. These data suggest that heavy ion could inhibit angiogenesis, thus leading to inhibition of tumor growth and metastasis. | |||||
| 書誌情報 |
放射線医学総合研究所重粒子線がん治療装置等共同利用研究報告書 巻 2002, p. 53-54, 発行日 2003-04 |
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| 出版者 | ||||||
| 出版者 | 放医研 | |||||
